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Vitamin D may improve success rate of H pylori eradication, finds recent study

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China: Vitamin D might protect people from Helicobacter pylori infection, a recent study published in the Helicobacter journal. Moreover, vitamin D can also improve the success rate of  H pylori eradication and individuals with vitamin D deficiency had a lower success rate of H pylori eradication.

According to the meta-analysis, the levels of vitamin D levels in H pylori‐positive patients were found to be lower than H pylori-negative patients.

H. pylori, a gram-negative and spiral-shaped bacterium that dwells on the gastric epithelium, is known to be associated with gastrointestinal diseases such as gastric ulcer, stomach cancer, and gastritis. However, lately, it has been shown to be associated with non-gastrointestinal diseases including autoimmune thyroid diseases, pre-eclampsia, and prostatitis. H.pylori infection has become a public health issue which has attracted the attention of many countries

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Various studies reported the relationship between H pylori and vitamin D, but there is some controversy around that. Chao Lu, Zhejiang University, Hangzhou, China, and colleagues aimed to conduct a meta‐analysis to clarify the relationship between vitamin D and H pylori infection, and vitamin D and H pylori eradication.
The researchers searched the online databases for studies published until June 1, 2019. In total ten articles were included.
Key findings of the study include:
  •  It was demonstrated that the average 25(OH)D level in H pylori‐positive patients was lower than H pylori‐negative (SMD = −0.53 ng/mL).
  • For H pylori eradication individuals, the result showed that an average 25(OH)D level in H pylori successful eradication individuals was higher than unsuccessful (SMD = 1.31 ng/mL).
  • Individuals with vitamin D deficiency had lower H pylori eradicate rate (OR = 0.09).
  • Sensitivity analysis showed that the meta‐analysis results were stable and reliable.

Read Also: Three drug Combo receives FDA approval for H. pylori infection

“In the future, more prospective studies are needed to validate the results of this study,” concluded the authors.

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The article, “Effect of vitamin D on Helicobacter pylori infection and eradication: A meta‐analysis” is published in the journal Helicobacter.

DOI: https://doi.org/10.1111/hel.12655

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Journal Information: Helicobacter




Source: Helicobacter journal

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