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Vitamin D deficiency can worsen chronic urticaria : Study

Vitamin D deficiency can worsen chronic urticaria : Study

Patients with chronic spontaneous urticaria(CSU) have reduced levels of vitamin D when compared to healthy individuals, according to a new study published in the Indian Dermatology Online. The study also demonstrated a significant negative association between disease severity and levels of serum vitamin D.

Shagufta Rather and his associates conducted a study to evaluate the relationship between vitamin D levels and chronic spontaneous urticaria (CSU) and compare with healthy age and sex-matched controls.

A hospital-based cross-sectional study which included 110 patients was conducted over a period of 1 year, For each patient, urticaria activity score (UAS) was calculated and autologous serum skin test (ASST) was performed. Plasma 25-hydroxyvitamin D [25-(OH)D] was analyzed by chemiluminescence method. Vitamin D values less than 20 ng/mL are considered as vitamin D deficiency, between 20 ng/mL and30 ng/mL as vitamin D insufficiency and values more than 30 ng/mL are categorized as sufficient.

The study found that the mean serum 25-(OH)D levels of CSU patients was 19.6 ± 6.9 ng/mL, whereas, in control group, the mean level was 38.5 ± 6.7. A significant negative correlation was found between vitamin D levels and UAS. The number of patients with ASST positivity was 44 (40%).

The authors said that the present guidelines for managing CSU do not include serum 25‑(OH)D level testing, but due to the possible immunomodulatory and anti-inflammatory effects of vitamin D, it might have a beneficial effect and complement to the already existing CSU treatment. Further randomized trials are needed to evaluate the aetiopathogenesis of vitamin D with regard to the immune response in patients with CSU.

Urticaria affects 15–25% of people at least once in their lifetime. It causes severe impairment on the quality of life. In a number of patients, chronic urticaria is associated with various aggravating factors including drugs, food and food additives, infections and infestations, systemic diseases, etc.50% cases of chronic urticaria remain idiopathic.

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Vinay Singh

Vinay Singh

Vinay Singh joined Medical Dialogue as Desk Editor in 2018. He covers the medical speciality news in different medical categories including Medical guidelines, updates from Medical Journals and Case Reports. He completed his graduation in Biotechnology from AAIDU and did his MBA from IILM Gurgaon. He can be contacted at . Contact no. 011-43720751
Source: With inputs from the journal Indian Dermatology Online

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