After adjusting for physical activity, body-mass index, smoking, alcohol, and fat and cholesterol intake, high intake of red meat, processed meat, or both was significantly associated with higher odds of NAFLD and insulin resistance (odds ratio, 1.47; 95% confidence interval, 1.04–2.09 and OR, 1.55; 95% CI, 1.07–2.23, respectively). Dose–response associations were observed multivariate analyses.Although a causal relationship cannot be established in this cross-sectional study, the observed dose–response relationship strengthens its likelihood. The findings are also consistent with a recent publication noting the association between eating a higher-quality diet and lower incidence of fatty liver disease.
The researchers found that:
- High consumption of red and/or processed meat is related to NAFLD and insulin resistance.
- Consumption of meat cooked in unhealthy methods is related to insulin resistance.
- Consumption of HCAs is related with insulin resistance.
- These associations are independent of saturated fat and cholesterol intake.
- If confirmed prospectively, limiting the consumption of unhealthy meats may be advised.
The researchers concluded that High consumption of red and/or processed meat is associated with both NAFLD and insulin resistance IR. High HCA intake is associated with IR.
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(NEJM JW Gastroenterol Apr 11 2018; [e-pub] and Gastroenterology20