Type 1 diabetes linked to poor muscle health in active Adults

Type 1 diabetes is a chronic condition characterized by destruction of beta cells responsible for insulin production. This type of diabetes is more prevalent in people below the age of 40 years.Thomas Hawke, professor of pathology and molecular medicine at McMaster, and colleagues conducted a study to evaluate the impact of type 1 diabetes on muscle activity of active young adults. The researchers found out that poor muscle health may develop in active young adults suffering from Type 1 diabetes.The study has been published today in Diabetologia, the journal of the European Association for the Study of Diabetes.

The research team analyzed muscle biopsies of young adults with and without Type 1 diabetes who exceed Diabetes Canada's recommended weekly levels for physical activity.

The researchers found structural and functional changes in the power generation parts of the cell, or mitochondria, of those with diabetes. Not only were the mitochondria less capable of producing energy for the muscle, they were also releasing high amounts of toxic reactive oxygen species, related to cell damage.

These changes could result in reduced metabolism, greater difficulty controlling blood glucose and, if left unchecked, an accelerated rate of developing disability. The study findings add poor muscle health to the list of better-known complications of Type 1 diabetes, including nerve damage, heart disease and kidney disorders.

“Now we know that even active people with diabetes have changes in their muscles that could impair their ability to manage blood sugar,” said Thomas Hawke, professor of pathology and molecular medicine at McMaster. “Knowing in the long term that this could contribute to faster development of disability, we can start to address it early on.”

Christopher Perry, study co-senior author and an associate professor in kinesiology and health sciences and the Muscle Health Research Centre at York University, added: “Skeletal muscle is our largest metabolic organ and is the primary tissue for clearing blood sugar after eating a meal, so we need to keep muscle as healthy as possible.”

With regular aerobic exercise, the amount of mitochondria in muscle increases, thereby helping muscle cells to use more glucose and become more efficient. Given this new data, Perry added that their study suggests that current guidelines for Type 1 diabetics may also need to be revised.

“We believe these dysfunctional mitochondria are what’s causing the muscle to not use glucose properly and to also damage muscle cells in the process. We were surprised to see the muscles were this unhealthy in young adults with Type 1 diabetes who were regularly active.”

Researchers say while further study is needed, revising evidence-based exercise guidelines, specific for those with Type 1 diabetes, may be required to keep them in the best health.

The team included researchers at York University, the University of Windsor and the German Center for Neurodegenerative Diseases as well as McMaster’s departments of pathology and molecular medicine, pediatrics, and kinesiology. Both Hawke and Perry are on the Board of Directors for the Canadian Society for Exercise Physiology.

The study was funded in part by the Natural Sciences and Engineering Research Council of Canada, the Canada Foundation for Innovation, and the James H. Cummings Foundation.

For more details click on the link: http://www.diabetologia-journal.org/files/Monaco.pdf