Sperm motility increases within one to two weeks of starting healthy diet: Study

Published On 2019-12-29 14:40 GMT   |   Update On 2021-08-11 10:46 GMT

Human sperm quality has declined worldwide in the last 40 years, by some accounts as much as 50–60%, causing serious concerns and implications for human fertility. It has been shown to be a worldwide problem but more pronounced in developed and industrialized countries, pointing to changes in modifiable lifestyle factors e.g. unhealthy diets, obesity, and pollution as the main causes.





The findings of a new study affirm that diet influences the motility of the sperm and the effects are noticeable after one to two weeks. Furthermore, human sperm are acutely sensitive to nutrient flux, both in terms of sperm motility and changes in sperm tsRNA.

Researchers at Linköping University have found that sperms are influenced by diet, and the effects arise rapidly. In the study in which healthy young men were fed a diet rich in sugar gives new insight into the function of sperm, and may in the long term contribute to new diagnostic methods to measure sperm quality. The study has been published in PLOS Biology.

"We see that diet influences the motility of the sperm, and we can link the changes to specific molecules in them. Our study has revealed rapid effects that are noticeable after one to two weeks", says Anita Öst, senior lecturer in the Department of Clinical and Experimental Medicine at Linköping University, and head of the study.

Sperm quality can be harmed by several environmental and lifestyle factors, of which obesity and related diseases, such as type 2 diabetes, are well-known risk factors for poor sperm quality. The research group that carried out the new study is interested in epigenetic phenomena, which involve physical properties or levels of gene expression changing, even when the genetic material, the DNA sequence, is not changed. In certain cases such epigenetic changes can lead to properties being transferred from a parent to offspring via the sperm or the egg.

In a previous study, the scientists showed that male fruit flies which had consumed excess sugar shortly before mating more often produced offspring who became overweight. Similar studies on mice have suggested that small fragments of RNA known as tsRNA play a role in these epigenetic phenomena that appear in the next generation. These RNA fragments are present in unusually large amounts in the sperm of many species, including humans, fruit flies and mice. So far, their function has not been examined in detail. Scientists have speculated that the RNA fragments in sperm may be involved in epigenetic phenomena, but it is too early to say whether this is the case in humans. The new study was initiated by the researchers to investigate whether high consumption of sugar affects the RNA fragments in human sperm.

The study examined 15 normal, non-smoking young men, who followed a diet in which they were given all food from the scientists for two weeks. The diet was based on the Nordic Nutrition Recommendations for healthy eating with one exception: during the second week, the researchers added sugar, corresponding to around 3.5 litres of fizzy drinks, or 450 grammes of confectionery, every day. The sperm quality and other indicators of the participants' health were investigated at the start of the study, after the first week (during which they ate a healthy diet), and after the second week (when the participants had additionally consumed large amounts of sugar).

At the beginning of the study, one-third of the participants had low sperm motility. Motility is one of several factors that influence sperm quality, and the fraction of people with low sperm motility in the study corresponded to that in the general population. The researchers were surprised to discover that the sperm motility of all participants became normal during the study.

"The study shows that sperm motility can be changed in a short period, and seems to be closely coupled to diet. This has important clinical implications. But we can't say whether it was the sugar that caused the effect, since it may be a component of the basic healthy diet that has a positive effect on the sperm", says Anita Öst.

The researchers also found that the small RNA fragments, which are linked to sperm motility, also changed. They are now planning to continue the work and investigate whether there is a link between male fertility and the RNA fragments in sperm. They will also determine whether the RNA code can be used for new diagnostic methods to measure sperm quality during in vitro fertilisation.

For further reference log on to:

PLOS Biology, published online on 26 December 2019, DOI: 10.1371/journal.pbio.3000559





Tags:    
Article Source : PLOS Biology

Disclaimer: This site is primarily intended for healthcare professionals. Any content/information on this website does not replace the advice of medical and/or health professionals and should not be construed as medical/diagnostic advice/endorsement or prescription. Use of this site is subject to our terms of use, privacy policy, advertisement policy. © 2020 Minerva Medical Treatment Pvt Ltd

Our comments section is governed by our Comments Policy . By posting comments at Medical Dialogues you automatically agree with our Comments Policy , Terms And Conditions and Privacy Policy .

Similar News