Intensive lowering of BP may improve erectile function in hypertensive men

Published On 2020-01-13 14:58 GMT | Update On 2021-08-09 10:32 GMT

The effect of intensive blood pressure control upon erectile function in men with hypertension without diabetes, is largely unknown.

The researchers conducted a study to examine the effects of intensive systolic blood pressure (SBP) lowering on erectile function in a multiethnic clinical trial of men with hypertension.

They found that intensive lowering of BP may improve erectile function in men with hypertension.The study has been published in The Journal of Sexual Medicine.

The researchers performed subgroup analyses from the Systolic Blood Pressure Intervention Trial ([SPRINT], in a sample of 1255 men aged 50 years or older with hypertension and increased cardiovascular disease risk. Participants were randomly assigned to an intensive treatment group (SBP goal of <120 mmHg) or a standard treatment group (SBP goal of <140 mmHg).

The main outcome measure was change in erectile function from baseline, using the 5-item International Index of Erectile Function (IIEF-5) total score, and erectile dysfunction ([ED]; defined as IIEF-5 score ≤21) after a median follow-up of 3 years.

After 4 years of follow-up, the authors found that non-Hispanic whites in the intensive SBP control group had substantially better IIEF-5 scores compared with the standard blood pressure control group. In contrast, non-Hispanic blacks had worse IIEF-5 scores in the intensive blood pressure control group when compared with the standard blood pressure control group. After adjusting for baseline scores, the differences appeared to be nonsignificant.

Although this study included a validated measure of erectile function, testosterone, other androgen, and estrogen levels were not assessed.

The researchers concluded that in a sample of male patients at high risk for cardiovascular events but without diabetes, targeting a SBP of less than 120 mm Hg, as compared with less than 140 mm Hg, resulted in statistically significant effects on erectile function that differed in accordance with race-ethnicity, although the clinical importance of the differences may be of small magnitude.

For further reference log on to:

https://doi.org/10.1016/j.jsxm.2019.11.256

Article Source : The Journal of Sexual Medicine

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Intensive lowering of BP may improve erectile function in hypertensive men

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