Ezetimibe-atorvastatin combo superior to atorvastatin alone for lipid lowering

Lipid-lowering drug combination ezetimibe with atorvastatin results in better outcomes than atorvastatin therapy alone, according to a review published in the journal Lipids in Health and Disease.

Although many previous studies have reported the efficacy of the combination versus monotherapy in lowering the levels of blood lipid, the conclusions have been controversial.

Jingpu Shi, The First Affiliated Hospital, China Medical University, Liaoning, China and colleagues conducted the systematic review and meta-analysis compared 4 dose groups commonly used in clinics ezetimibe (10 mg) + atorvastatin (10 mg) vs atorvastatin monotherapy (10 and 20 mg), ezetimibe (10 mg) + atorvastatin (20 mg) vs. atorvastatin (40 mg) and ezetimibe (10 mg) + atorvastatin (40 mg) vs atorvastatin (80 mg) therapies.

Also Read: Lipid lowering agents reduce incidence and progression of diabetic retinopathy