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World’s smallest device to monitor phototherapy in neonatal jaundice

World’s smallest device to monitor phototherapy in neonatal jaundice
World’s smallest wearable device to monitor UV light exposure has been  developed by scientists that  shall come handy in treatment of neonatal jaundice, skin diseases, seasonal affective disorder and reduce risk of sunburns and skin cancer.The device enables precision phototherapy for these health conditions, and it can monitor, separately and accurately, UVB and UVA exposure for people at high risk for melanoma, a deadly form of skin cancer. The sensor can help warn of impending sunburn to people having exposure to sun for recreation.

Northwestern Medicine and Northwestern’s McCormick School of Engineering scientists  have developed the device  to measure exposure to light across multiple wavelengths, from the ultra violet (UV), to visible and even infrared parts of the solar spectrum.  The wafer-thin, feather-light sensor can fit on a fingernail and precisely measures a person’s exposure to UV light from the sun. It can record up to three separate wavelengths of light at one time.

The devices shall be able to alert people to their UVA exposure, enabling them to take action to protect their skin from sun damage.The  underlying Priciples of device and its  clinical applications have been  reported in a  study  published in Science Translational Medicine.
The device has been designed by a team of researchers in the group of John Rogers, the Louis Simpson and Kimberly Querrey Professor of Materials Science and Engineering, Biomedical Engineering in the McCormick School of Engineering and a professor of neurological surgery at Northwestern’s Feinberg School of Medicine.

“From the standpoint of the user, it couldn’t be easier to use—it’s always on yet never needs to be recharged,” Rogers said. “It weighs as much as a raindrop, has a diameter smaller than that of an M&M and the thickness of a credit card. You can mount it on your hat or glue it to your sunglasses or watch.”

It’s also rugged, waterproof and doesn’t need a battery. “There are no switches or interfaces to wear out, and it is completely sealed in a thin laye r of transparent plastic,” Rogers said. “It interacts wirelessly with your phone. We think that it will last forever.”

Rogers tried to break it. His students dunked devices in boiling water and in a simulated washing machine. They still worked.

Northwestern scientists are particularly excited about the device’s use for measuring the entire UV spectrum and accumulating total daily exposure.

“There is a critical need for technologies that can accurately measure and promote safe UV exposure at a personalized level in natural environments,” said co-senior author Dr. Steve Xu, instructor in dermatology at Feinberg and a Northwestern Medicine dermatologist.

“We hope people with information about their UV exposure will develop healthier habits when out in the sun,” Xu said. “UV light is ubiquitous and carcinogenic. Skin cancer is the most common type of cancer worldwide. Right now, people don’t know how much UV light they are actually getting. This device helps you maintain an awareness and for skin cancer survivors, could also keep their dermatologists informed.”

World's smallest wearable device warns of UV exposure, enables precision phototherapy
The sensors can be used to monitor infants undergoing phototherapy treatment. Credit: S.Y. Heo et al., Science Translational Medicine (2018)

Light wavelengths interact with the skin and body in different ways, the scientists said.

“Being able to split out and separately measure exposure to different wavelengths of light is really important,” Rogers said. “UVB is the shortest wavelength and the most dangerous in terms of developing cancer. A single photon of UVB light is 1,000 times more erythrogenic, or redness inducing, compared to a single photon of UVA.”

In addition, the intensity of the biological effect of light changes constantly depending on weather patterns, time and space.

“If you’re out in the sun at noon in the Caribbean, that sunlight energy is very different than noon on the same day in Chicago,” Xu said.

Skin cancer is reaching epidemic proportions in the U.S leading to high morbidity and mortality and last but not the least high economic burden.

How the device works:Light passes through a window in the sensor and strikes a millimeter-scale semiconductor photodetector. This device produces a minute electrical current with a magnitude proportional to the intensity of the light. This current passes to an electronic component called a capacitor where the associated charge is captured and stored. A communication chip embedded in the sensor reads the voltage across this capacitor and passes the result digitally and wirelessly to the user’s smartphone. At the same time, it discharges the capacitor, thereby resetting the device.

Multiple detectors and capacitors allow measurements of UVB and UVA exposure separately. The device communicates with the users’ phone to access weather and global UV index information (the amount of light coming through the clouds). By combining this information, the user can infer how much time they have been in the direct sun and out of shade. The user’s phone can then send an alert if they have been in the sun too long and need to duck into the shade.

The device will enable the doctors to give accurate dosing of phototherapy to the patients .At present the amount of light patients actually receive from phototherapy is not measured. “We know that the lamps for phototherapy are not uniform in their output—a sensor like this can help target problem areas of the skin that aren’t getting better,” said Xu. Doctors don’t know how much blue light a jaundiced newborn is actually absorbing or how much white light a patient with seasonal affective disorder gets from a light box. The new device will measure this for the first time and allow doctors to optimize the therapy by adjusting the position of the patient or the light source.

Because the device operates in an “always on” mode, its measurements are more precise and accurate than any other light dosimeter now available, the scientists said. Current dosimeters only sample light intensity briefly at set time intervals and assume that the light intensity at times between those measurements is constant, which is not necessarily the case, especially in active, outdoor use scenarios. They are also clunky, heavy and expensive.

More information: S.Y. Heo el al., “Wireless, battery-free, flexible, miniaturized dosimeters monitor exposure to solar radiation and to light for phototherapy,” Science Translational Medicine (2018). … scitranslmed.aau1643

Source: self

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