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Vitamin D supplementation with antihistamine improves allergic rhinitis symptoms

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Vitamin D supplementation with antihistamine improves allergic rhinitis symptoms, finds study.

Vitamin D supplementation along with antihistamine improves allergic symptoms in allergic rhinitis (AR) patients with vitamin D deficiency, according to a recent study published in the European Archives of Oto-Rhino-Laryngology journal.

Vitamin D is usually got through food and by exposure to sunlight. For most adults, vitamin D deficiency isn’t a concern. Some, especially those with dark skin and adults older than 65, are at higher risk of the condition.

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Bashir Rasoulian, Mashhad University of Medical Sciences, Mashhad, Iran, and colleagues aimed to determine whether short-term (2 months) vitamin D supplementation could improve the allergic symptoms in AR patients. 

Allergic rhinitis is defined as symptoms of sneezing, rhinorrhea, nasal obstruction, and pruritus caused by immunoglobulin E (IgE)‐mediated reactions against inhaled allergens and involving mucosal inflammation, which is driven by T‐helper 2 (Th2) cells. It may be seasonal or perennial.

The researchers enrolled  80 patients with allergic rhinitis and vitamin D deficiency in this randomized double-blind placebo-controlled clinical trial and followed up from Nov. 2017–2018. They were divided into two groups; the study group (n=35) was prescribed vitamin D plus routine antihistamine medication (cetirizine) and the control group (n=33) received cetirizine plus placebo.

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The clinical symptoms questionnaire was completed at baseline and after 4 and 8 weeks of treatment initiation. Vitamin D levels were re-measured at the end of the 8-week treatment course.

Also Read: Good News! Allergic rhinitis linked to decreased risk of multiple cancers

Key findings include:

  • At study initiation, the mean vitamin D level was 14 ng/ml and 14.67 ng/ml in the study and control groups, respectively, indicating no significant difference. 
  • The mean serum vitamin D level at 8 weeks of treatment in the study group (24.08 ng/ml) indicated a statistically meaningful difference with the mean vitamin D level at baseline. 
  • Comparison of the mean scores of symptoms severity showed no significant difference between the two groups at study initiation and 4 weeks later, whereas a significant difference was obtained between baseline and 8 weeks of treatment initiation. 

Also Read: FDA approves Oralair for grass pollen-induced allergic rhinitis in kids

“Based on our findings, it can be concluded that vitamin D supplementation along with antihistamines can result in relative symptoms improvement in AR patients with vitamin D deficiency,” wrote the authors.

To read the complete study log on to https://doi.org/10.1007/s00405-019-05546-x




Source: self

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