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    • Vitamin D...

    Vitamin D supplementation less effective in Obese individuals, confirms study

    Written by Dr. Kamal Kant Kohli Kohli Published On 2019-02-22T19:28:54+05:30  |  Updated On 19 Aug 2021 4:41 PM IST

    A new study confirms that vitamin D supplementation is less effective in the presence of obesity, and it uncovers a biological mechanism to explain this observation.The study has appeared in Journal of Bone and Mineral Research.


    Normal vitamin D levels are critical for optimal health and at the same time vitamin D deficiency is a worldwide public health problem. Vitamin D insufficiency is most commonly due to inadequate cutaneous synthesis of cholecalciferol and/or insufficient intake of vitamin D, but can also arise as a consequence of pathological states such as obesity.


    Please also read -How Vitamin D deficiency leads to cognitive decline,finds Study

    Serum concentrations of 25(OH)D (calcidiol) are low in obesity, and fail to increase appropriately after vitamin D supplementation.


    The study reveals that obese mice have very low levels of the enzyme in the liver that converts vitamin D into 25-hydroxyvitamin D (calcidiol), which is the major form of vitamin D in the blood. Therefore, it may be more effective to treat vitamin D insufficiency in obese individuals with calcidiol rather than with other forms of vitamin D.

    Please also read -Vitamin D benefits in drug-resistant Tuberculosis, finds study

    "Low circulating levels of 25-hydroxyvitamin D are common in obesity and have been attributed to sequestration of vitamin D in fat cells. Here we propose a second mechanism with greater biological implications: obesity reduces the ability of the liver to convert vitamin D into 25-hydroxyvitamin D," said lead author Dr. Jeffrey Roizen, of The Children's Hospital of Philadelphia. "Our observations show that this early step in activating vitamin D is influenced by obesity, and suggest that obesity-related effects on the liver can have clinically important systemic effects on bone and mineral metabolism. Further, while we often think of low vitamin D causing obesity, this work shows that an illness or pathology (like obesity) can cause low vitamin D."

    BMIcholecalciferolCutaneousDeficiencyeffecteffectivehighinadequateindividualsinsufficientintakeJournal of Bone and Mineral Researchlesslowlow vitamin DmoreobeseObesityoverweightpersonsrelatedrelationshipsunlightsupplementationsupplementssynthesisVitamin Dweight
    Source : american society for bone and mineral research

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    Dr. Kamal Kant Kohli Kohli
    Dr. Kamal Kant Kohli Kohli
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