In a secondary Analysis of a conducted in Zurich, Switzerland, authors found that Vitamin D leads to signiﬁcant improvement in mental health scores in elderly at end of one year. The findings of the study have appeared in the Journal American Geriatric Society.
Globally, 1 in 5 adults experiences a mental disorder each year, and 1 in 3 adults do so across their lifetime. Older adults are at increased risk for mental health decline and depression. Among adults 60 years and older,17% of years lived with disability are attributed to mental or neurologic disorders, mainly depression and dementia.
Dr Alenka Gugger at Department of Geriatrics and Aging Research, University Hospital Zurich and University of Zurich, Switzerland and colleagues conducted a double-blind randomized clinical trial to test the effect of monthly high-dose vitamin D supplementation on mental health in pre-frail older adults.
In a new study of a 1-year, double-blind, randomized clinical trial conducted in Zurich, Switzerland, authors assessed 200 community-dwelling adults of aged ≥ 70 years to examine the influence of monthly high-dose vitamin D supplementation on mental health in pre-frail older adults. Subjects were given 24,000 IU vitamin D3 (considered a standard of care), 60,000 IU vitamin D3, or 24,000 IU vitamin D3 plus 300 μg calcifediol per month.
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The primary endpoint was the Mental Component Summary (MCS) of the SF-36. Secondary endpoints were the SF-36 Mental Health (MH) subscale and the Geriatric Depression Scale (GDS-15). The investigators observed substantial improvements in mental health scores among candidates with the highest 25(OH)D quartile at 12 months (44.7-98.9 ng/mL) after adjusting for confounders, and this association was strongest among subjects who were vitamin D deficient at baseline.
It was found that compared with the standard monthly dose of 24,000 IU, higher monthly doses of vitamin D3 did not provide any mental health benefit. However, higher 25(OH)D levels at 12-month follow-up were associated with a small but statistically significant improvement in mental health scores, regardless of vitamin D treatment dose.
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The researchers concluded that for mental health, our study suggests no beneﬁt of higher monthly doses of vitamin D compared with the standard monthly dose of 24 000 IU. However, irrespective of vitamin D treatment dose, achieving higher 25(OH)D levels at 12-month follow-up was associated with a small, clinically uncertain but statistically signiﬁcant improvement in mental health scores.
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