Speciality Medical Dialogues
    • facebook
    • twitter
    Login Register
    • facebook
    • twitter
    Login Register
    • Medical Dialogues
    • Education Dialogues
    • Business Dialogues
    • Medical Jobs
    • Medical Matrimony
    • MD Brand Connect
    Speciality Medical Dialogues
    • Editorial
    • News
        • Anesthesiology
        • Cancer
        • Cardiac Sciences
        • Critical Care
        • Dentistry
        • Dermatology
        • Diabetes and Endo
        • Diagnostics
        • ENT
        • Featured Research
        • Gastroenterology
        • Geriatrics
        • Medicine
        • Nephrology
        • Neurosciences
        • Nursing
        • Obs and Gynae
        • Ophthalmology
        • Orthopaedics
        • Paediatrics
        • Parmedics
        • Pharmacy
        • Psychiatry
        • Pulmonology
        • Radiology
        • Surgery
        • Urology
    • Practice Guidelines
        • Anesthesiology Guidelines
        • Cancer Guidelines
        • Cardiac Sciences Guidelines
        • Critical Care Guidelines
        • Dentistry Guidelines
        • Dermatology Guidelines
        • Diabetes and Endo Guidelines
        • Diagnostics Guidelines
        • ENT Guidelines
        • Featured Practice Guidelines
        • Gastroenterology Guidelines
        • Geriatrics Guidelines
        • Medicine Guidelines
        • Nephrology Guidelines
        • Neurosciences Guidelines
        • Obs and Gynae Guidelines
        • Ophthalmology Guidelines
        • Orthopaedics Guidelines
        • Paediatrics Guidelines
        • Psychiatry Guidelines
        • Pulmonology Guidelines
        • Radiology Guidelines
        • Surgery Guidelines
        • Urology Guidelines
    LoginRegister
    Speciality Medical Dialogues
    LoginRegister
    • Home
    • Editorial
    • News
      • Anesthesiology
      • Cancer
      • Cardiac Sciences
      • Critical Care
      • Dentistry
      • Dermatology
      • Diabetes and Endo
      • Diagnostics
      • ENT
      • Featured Research
      • Gastroenterology
      • Geriatrics
      • Medicine
      • Nephrology
      • Neurosciences
      • Nursing
      • Obs and Gynae
      • Ophthalmology
      • Orthopaedics
      • Paediatrics
      • Parmedics
      • Pharmacy
      • Psychiatry
      • Pulmonology
      • Radiology
      • Surgery
      • Urology
    • Practice Guidelines
      • Anesthesiology Guidelines
      • Cancer Guidelines
      • Cardiac Sciences Guidelines
      • Critical Care Guidelines
      • Dentistry Guidelines
      • Dermatology Guidelines
      • Diabetes and Endo Guidelines
      • Diagnostics Guidelines
      • ENT Guidelines
      • Featured Practice Guidelines
      • Gastroenterology Guidelines
      • Geriatrics Guidelines
      • Medicine Guidelines
      • Nephrology Guidelines
      • Neurosciences Guidelines
      • Obs and Gynae Guidelines
      • Ophthalmology Guidelines
      • Orthopaedics Guidelines
      • Paediatrics Guidelines
      • Psychiatry Guidelines
      • Pulmonology Guidelines
      • Radiology Guidelines
      • Surgery Guidelines
      • Urology Guidelines
    • Home
    • News
    • Cardiac Sciences
    • Use of furosemide in...

    Use of furosemide in children with CHD linked to increased risk of bone fractures

    Written by Medha Baranwal Baranwal Published On 2018-05-25T19:15:52+05:30  |  Updated On 25 May 2018 7:15 PM IST
    Use of furosemide in children with CHD linked to increased risk of bone fractures

    The administration of furosemide (Lasix) therapy in children with congenital heart disease (CHD) is associated with an increased risk of bone fractures in them, according to a new study published in The Journal of Pediatrics.


    The study was conducted by Ji Haeng Heo, Genesis Research, Hoboken, NJ, and colleagues to determine the association of furosemide therapy with the incidence of bone fractures in children with congenital heart disease.


    CHD is a defect of the heart's structure present at birth. The problem can affect the blood vessels, the heart valves, and the heart walls. It disrupts the normal blood flow through the heart that impacts normal breathing.


    Furosemide is a water pill (loop diuretic) that is used for the treatment of fluid build-up caused due to kidney disease, congestive heart failure, and liver scarring. It prevents too much absorption of salt by the body allowing the salt to be passed in the urine. It is frequently prescribed for children with heart disease, is known to increase urinary excretion of calcium and is suspected to be associated with bone fractures in adults.






    For the research, the investigators reviewed data in the Texas Medicaid Database from 2008 through 2014 on 3912 patients (<12 years old) with congenital heart defects (CHD), cardiomyopathy, or heart failure. Of these, 254 (6%) were adherent furosemide users (≥70% medication possession ratio), 724 (19%) were nonadherent users (<70% MPR), and 2934 (75%) were propensity-score–matched nonusers. Few other diuretics were coadministered.






    Results at a median follow-up of about 3 years were as follows:




    • The incidence of fracture was higher in adherent and nonadherent furosemide users than in nonusers (9.1% and 7.2% vs. 5.0%; P<0.001).

    • The risk of fracture was higher in children with a dual diagnosis of CHD/cardiomyopathy or CHD/heart failure than in those with CHD only.

    • The risk for fracture was 87% higher in adherent users than in nonusers and was 54% higher in nonadherent users than in nonusers.

    • The risk of fracture was higher in white children than in black or Hispanic children.

    • The risk of fracture was higher in children receiving versus not receiving proton-pump inhibitors (PPIs).


    "Children with CHD who are receiving furosemide have an excess risk for fractures, especially if they have cardiomyopathy, are white, and take PPIs," concluded the authors.







    For further information click on the link: https://doi.org/10.1016/j.jpeds.2018.03.077


    bone fracturecardiomyopathycongenital heart diseaseDiureticsfracture in childrenfracturesfurosemidefurosemide therapyheart abnormalityheart failureJi Haeng HeoLasixloop diureticpediatricsPPIsProton pump inhibitorsThe Journal of Pediatricswater pill
    Source : With inputs from The Journal of Pediatrics

    Disclaimer: This site is primarily intended for healthcare professionals. Any content/information on this website does not replace the advice of medical and/or health professionals and should not be construed as medical/diagnostic advice/endorsement or prescription. Use of this site is subject to our terms of use, privacy policy, advertisement policy. © 2020 Minerva Medical Treatment Pvt Ltd

    Medha Baranwal Baranwal
    Medha Baranwal Baranwal
      Show Full Article
      Next Story
      Similar Posts
      NO DATA FOUND

      • Email: info@medicaldialogues.in
      • Phone: 011 - 4372 0751

      Website Last Updated On : 12 Oct 2022 7:06 AM GMT
      Company
      • About Us
      • Contact Us
      • Our Team
      • Reach our Editor
      • Feedback
      • Submit Article
      Ads & Legal
      • Advertise
      • Advertise Policy
      • Terms and Conditions
      • Privacy Policy
      • Editorial Policy
      • Comments Policy
      • Disclamier
      Medical Dialogues is health news portal designed to update medical and healthcare professionals but does not limit/block other interested parties from accessing our general health content. The health content on Medical Dialogues and its subdomains is created and/or edited by our expert team, that includes doctors, healthcare researchers and scientific writers, who review all medical information to keep them in line with the latest evidence-based medical information and accepted health guidelines by established medical organisations of the world.

      Any content/information on this website does not replace the advice of medical and/or health professionals and should not be construed as medical/diagnostic advice/endorsement or prescription.Use of this site is subject to our terms of use, privacy policy, advertisement policy. You can check out disclaimers here. © 2025 Minerva Medical Treatment Pvt Ltd

      © 2025 - Medical Dialogues. All Rights Reserved.
      Powered By: Hocalwire
      X
      We use cookies for analytics, advertising and to improve our site. You agree to our use of cookies by continuing to use our site. To know more, see our Cookie Policy and Cookie Settings.Ok