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Type 2 Diabetes in younger patients not a Benign Condition


Type 2 Diabetes in younger patients not a Benign Condition

In a nationwide study conducted in Denmark, it was observed that younger patients diagnosed with type 2 diabetes were more likely to have cardiovascular disease (CVD) risk factors — such as severe obesity, hyperlipidemia, low-grade inflammation, physical inactivity, and smoking as compared to adults who developed diabetes later in life,

Dr. Anne Bo and colleagues conducted a study to examine the association between early onset of type 2 diabetes mellitus (DM) and clinical and behavioral risk factors for later complications of diabetes.The researchers found that CVD risk factors was highest in patients with early-onset diabetes (age 18 to 45) and decreased stepwise as the age of diabetes diagnosis increased. The study was published in Diabetes/Metabolism Research and Reviews.

The researchers conducted a cross‐sectional study of 5115 persons with incident type 2 DM enrolled during 2010‐2015 in the Danish Centre for Strategic Research in Type 2 Diabetes‐cohort. They  compared risk factors at time of diagnosis among those diagnosed at ≤45 years (earlyonset) with diagnosis age 46 to 55, 56 to 65 (average onset = reference), 66 to 75, and >75 years(late onset). Prevalence ratios (PRs) were computed by using Poisson regression.Results: Poor glucose control, ie, HbA1c ≥ 75 mmol/mol (≥9.0%) in the early‐, average‐, and late‐onset groups was observed in 12%, 7%, and 1%, respectively (PR 1.70 [95% confidence intervals (CI) 1.27, 2.28] and PR 0.17 [95% CI 0.06, 0.45]). A similar age gradient was observed for severe obesity (body mass index > 40 kg/m2: 19% vs. 8% vs. 2%; PR 2.41 [95% CI 1.83,3.18] and 0.21 (95% CI 0.08, 0.57]), dyslipidemia (90% vs. 79% vs. 68%; PR 1.14 [95% CI 1.10,1.19] and 0.86 [95% CI 0.79, 0.93]), and low‐grade inflammation (C‐reactive protein > 3.0 mg/L:53% vs. 38% vs. 26%; PR 1.41 [95% CI 1.12, 1.78] and 0.68 [95% CI 0.42, 1.11]). Daily smokingwas more frequent and meeting physical activity recommendations less likely in persons with bearly‐onset type 2 DM.

The authors concluded that they found a clear age gradient, with increasing prevalence of clinical and behavioural risk factors the younger the onset age of type 2 DM.The study suggests that patients with early-onset diabetes  had poorer glycemic control than other patients and were more prone to complications.Therefore  younger persons with early‐onset type 2 DM need clinical awareness and support.

 

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Dr. Kamal Kant Kohli

Dr. Kamal Kant Kohli

A Medical practitioner with a flair for writing medical articles, Dr Kamal Kant Kohli joined Medical Dialogues as an Editor-in-Chief for the Speciality Medical Dialogues. Before Joining Medical Dialogues, he has served as the Hony. Secretary of the Delhi Medical Association as well as the chairman of Anti-Quackery Committee in Delhi and worked with other Medical Councils of India. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751
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  1. user
    Vivek Hattangadi December 26, 2017, 6:49 pm

    Another major issue in young diabetics and hypertensives is it accelerates the problem of hippocampus decay (formation of beta-amyloid plaques) and sets the stage for

    1. Executive Function Deficit

    2. Which probably is a marker for Alzheimer\’s Disease

    Vivek Hattangadi

  2. This is true that cases of early onset of type 2 DM is increasing day by day and probable risk factors are- genetic factor like mother or father or both are suffering from DM2, life style, obesity, High BP, food habits etc. By changing life style the onset can be modified but not eliminated. There should be good repeated counselling & communication for both diet & drug.