Twins should be delivered at 37 weeks’ gestation to minimise stillbirths and newborn deaths, and there is no clear evidence to support routine delivery before 36 week’s gestation, finds a large international study in The BMJ.
It is well known that the risk of stillbirth is higher in twin pregnancies than in singleton pregnancies. Uncomplicated twin pregnancies are often delivered early in an attempt to prevent stillbirth, but the optimal gestational age for delivery that minimises risks to newborns is not known.
Current recommendations vary on the timing of delivery, starting from 34 up to 37 weeks’ gestation in monochorionic twin pregnancies (twins that share the same placenta) and from 37 up to 39 weeks in dichorionic twin pregnancies (twins that have two individual placentas).
So an international team of researchers decided to examine the evidence behind these recommendations.
They analysed the results of 32 studies, published within the past 10 years, of women with uncomplicated twin pregnancies that reported rates of stillbirth and neonatal mortality (defined as death up to 28 days after delivery) at various gestational ages after 34 weeks.
Overall the studies included 35,171 twin pregnancies (29,685 dichorionic and 5,486 monochorionic). Study design and quality were taken into account to minimise bias.
The researchers looked specifically at the balance between the risk of stillbirths from expectant management (‘watchful waiting’) and the risk of neonatal death from delivery beyond 34 weeks.
They found that, in dichorionic pregnancies, the risk of stillbirths and neonatal death were balanced until 37 weeks’ gestation. However, delay in delivery by a week (to 38 weeks) led to an additional 8.8 deaths per 1,000 due to an increase in stillbirth.
In monochorionic pregnancies, the risk of stillbirth appears to be higher than neonatal death beyond 36 weeks’ gestation. But more data are needed to make a clear recommendation on best time to deliver monochorionic pregnancies.
Rates of neonatal morbidity (including respiratory distress syndrome, septicaemia, or neonatal seizures) and admission to the neonatal intensive care unit showed a consistent reduction with increasing gestational age in both monochorionic and dichorionic pregnancies.
Based on these estimates, the researchers suggest that, for women with dichorionic twin pregnancies, delivery should be considered at 37 weeks’ gestation “to prevent the significant increase in stillbirths associated with expectant management compared with the risk of neonatal deaths associated with early delivery.”
In monochorionic twin pregnancies, “there is no clear evidence to support routine delivery before 36 weeks’ gestation,” they say.
The authors point out that the actual risk of stillbirth near term “might be higher than reported estimates because of the policy of planned delivery in twin pregnancies.” But say, “our study provides comprehensive estimates comparing risks of stillbirth and neonatal mortality at various gestational ages, which is required for the planning of delivery in uncomplicated twin pregnancies.”
This information “will complement the ongoing national and international efforts to reduce the rates of stillbirths and unexpected neonatal complications in babies born near term,” they conclude.
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Fiona Cheong-See, Ewoud Schuit, David Arroyo-Manzano, Asma Khalil, Jon Barrett, K S Joseph, Elizabeth Asztalos, Karien Hack, Liesbeth Lewi, Arianne Lim, Sophie Liem, Jane E Norman, John Morrison, C Andrew Combs, Thomas J Garite, Kimberly Maurel, Vicente Serra, Alfredo Perales, Line Rode, Katharina Worda, Anwar Nassar, Mona Aboulghar, Dwight Rouse, Elizabeth Thom, Fionnuala Breathnach, Soichiro Nakayama, Francesca Maria Russo, Julian N Robinson, Jodie M Dodd, Roger B Newman, Sohinee Bhattacharya, Selphee Tang, Ben Willem J Mol, Javier Zamora, Basky Thilaganathan, Shakila Thangaratinam.Prospective risk of stillbirth and neonatal complications in twin pregnancies: systematic review and meta-analysis. BMJ, 2016; i4353 DOI: 10.1136/bmj.i4353