This site is intended for Healthcare professionals.
×

Sivelestat is new potential therapy for portal hypertension


Sivelestat  is new potential therapy for portal hypertension

The drug sivelestat may effectively lower portal hypertension, improving symptoms and outcomes for those patients, according to a new study by Mayo Clinic researchers.

It is a potentially life-threatening condition associated with cirrhosis and other chronic liver diseases.The study has been posted in March on Gastroenterology, the online journal of the American Gastroenterological Association.

Portal hypertension is associated with cirrhosis and other chronic liver diseases. There is an increase in pressure within the portal vein that carries blood from abdominal organs to the liver.Unfortunately options have been  limited for treating portal hypertension.

................................ Advertisement ................................

According to the study, the drug sivelestat may effectively lower portal hypertension, improving symptoms and outcomes for those patients. The study results were obtained from mouse models but have since been confirmed in liver samples from humans, according to Vijay Shah, M.D., a Mayo Clinic gastroenterologist and senior author.

................................ Advertisement ................................

“This was an exciting confirmation of our findings and their applicability to human disease,” Dr. Shah says. “Sivelestat has been safely used in humans with acute lung injury and bronchopulmonary dysplasia. This suggests that sivelestat and similar drugs constitute a potential means to decrease portal hypertension in patients with chronic liver disease.”

The Mayo study showed that deposits of fibrin — microvascular blood clots — contributed to portal hypertension, and inflammatory cells known as neutrophils contributed to the formation of fibrin. By inhibiting neutrophil function with sivelestat, they were able to decrease portal hypertension.

“Neutrophils had not previously been identified as significant drivers of portal hypertension,” says Moira Hilscher, M.D., the paper’s first author. Results were verified in two different models of chronic liver disease.

“The study paves the way for developing new drugs and repurposing of existing compounds to target inflammation in the liver driven by disease-related mechanical forces,” says Dr. Hilscher. “Given the increasing prevalence of advanced liver disease due to alcohol and obesity, this is clearly an unmet need.”




Source: self

Share your Opinion Disclaimer

Sort by: Newest | Oldest | Most Voted
  1. user
    Dr Sutender Gaur May 1, 2019, 6:07 pm

    exellent article on liver