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    • Role of AMH as...

    Role of AMH as Diagnostic Tool for Polycystic Ovarian Syndrome

    Written by Dr. Kamal Kant Kohli Kohli Published On 2017-12-25T19:20:51+05:30  |  Updated On 25 Dec 2017 7:20 PM IST
    Role of AMH as Diagnostic Tool for Polycystic Ovarian Syndrome

    “ Role of AMH as Diagnostic Tool for Polycystic Ovarian Syndrome” was a prospective case-control study conducted by us.The same was published in The Journal of Obstetrics and Gynecology of India. An anti-mullerian hormone test (AMH) can be done at any time in the menstrual cycle, as your amh levels are stable throughout the cycle. It is a marker for ovarian (egg) reserve and is assessed via an AMH blood test.


    The study comprised of 45 women with PCOS, diagnosed using Rotterdam criteria and 45 Non-PCOS women as controls. Clinical history, BMI, Ferriman Gallwey score, FSH, LH, estradiol, TSH, prolactin, total testosterone, AMH level and pelvic USG was done for all the women. PCOS cases and control were matched for age and BMI. Median AMH levels in PCOS women was almost twice that in controls, being 4.32ng/ml 2.32 ng/ ml respectively (p=0.001).Diagnostic potential of AMH alone for PCOS was highest at a cut off of 3.44 ng/ml with sensitivity and specificity of 77.78% and 68.89% respectively. AMH when used as the 4th parameter as an adjunct to existing three Rotterdam criteria of oligomenorrhea (OA), hyperandrogenism (HA), Polycystic ovarian Morphology (PCOM), OA+HA+PCOM+AMH (any three out of four) yielded sensitivity of 80 %.However, when AMH was used to replace PCOM in Rotterdam Criteria OA+HA+AMH (any two out of three) or OA/HA+AMH resulted in the sensitivity of 86.67% and 71.11% respectively.


    Hence we concluded that although AMH was significantly higher in PCOS than in controls yet it could not effectively diagnose PCOS when used independently. However, when AMH was used as an adjunct to existing Rotterdam Criteria especially when it was used to replace PCOM, then it was found to be an effective diagnostic tool for PCOS.



    Dr Upma Saxena


    The author is MD (Gynecologist) and is Prof. at Vardhman Mahavir Medical College at Safdarjung New Delhi. She is a member Editorial Board, Gynecologist at Specialty Medical Dialogues.


    BMIdiagnosticDr Upma Saxenahyperandrogenismmenstrual cycleoligomenorrheaPCOSPolycystic ovarian MorphologyPolycystic Ovarian SyndromeThe Journal of Obstetrics and Gynecology

    Disclaimer: This site is primarily intended for healthcare professionals. Any content/information on this website does not replace the advice of medical and/or health professionals and should not be construed as medical/diagnostic advice/endorsement or prescription. Use of this site is subject to our terms of use, privacy policy, advertisement policy. © 2020 Minerva Medical Treatment Pvt Ltd

    Dr. Kamal Kant Kohli Kohli
    Dr. Kamal Kant Kohli Kohli
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