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Regular Benzodiazepines use increase risk of Alzheimer’s disease


Regular Benzodiazepines use increase risk of Alzheimer’s disease
The use of benzodiazepines and related drugs (Z drugs) is associated with a modestly increased risk of Alzheimer’s disease, according to a recent study from the University of Eastern Finland. The risk increase was similar with both benzodiazepines and Z drugs regardless of their half-life. The results were published in Acta Psychiatrica Scandinavica.

Even though the increased risk for Alzheimer’s disease was small in this study, the threshold for prescribing benzodiazepines and related drugs should be high enough due to their several adverse effects and events, such as falls. These medications are commonly used for sleep problems, but their effectiveness for this indication diminishes over weeks or months. However, the risk of adverse events remains in longer-term use.

The study was conducted in the nationwide MEDALZ cohort which included all Finnish community dwellers with newly diagnosed Alzheimer’s disease in 2005-2011 (70,719 persons), and their age, sex, and region of residence matched controls (282,862 persons). Medicine use since 1995 was extracted from the Finnish Prescription Register. Many chronic disorders, substance abuse, socioeconomic position and use of antidepressants and antipsychotics were taken into account. To account for reverse causality, drug use within 5 years before Alzheimer’s disease diagnosis was not taken into account.
For details click on the link: http://dx.doi.org/10.1111/acps.12909

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Hina
Hine Zahid Joined Medical Dialogue in 2017 with a passion to work as a Reporter. She covers all the stories related to Medical guidelines, Medical Journals, rare medical surgeries as well as all the updates in the medical field. Email: hina@medicaldialogues.in. Contact no. 011-43720751
Source: With inputs from Acta Psychiatrica Scandinavica

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