Taiwan: Psoriasis patients are at higher risk of developing thyroid diseases including hypothyroidism, thyroiditis, hyperthyroidism, and specific autoimmune thyroid disease (Grave’s disease and Hashimoto’s thyroiditis), according to a new study.
Findings of the study, published in the Journal of the American Academy of Dermatology, may be helpful in risk stratification for thyroid disease in patients with psoriatic disease. Endocrinological consultation may be offered to psoriasis patients with thyroid symptoms.
The association between psoriasis and thyroid diseases has been uncertain. Ching-Chi Chi, Department of Dermatology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan, and colleagues conducted this cohort study to examine the risk of thyroid diseases in psoriasis patients.
Psoriatic arthritis (PsA) is a chronic inflammatory musculoskeletal disease commonly found in psoriasis patients. It can quickly lead to irreversible joint damage, functional limitation and quality-of-life impairment. Psoriasis is a skin disease that appearance of red, scaly patches on the skin.
The researchers used Taiwan’s National Health Insurance Research Database to conduct a nationwide cohort study. The study involved 13,266 patients with psoriatic arthritis (mean age, 43.17 years), 149,576 with psoriasis alone (mean age, 45.11 years), and 162,842 without psoriasis (mean age, 44.95 years).
- Compared with individuals without psoriasis, those with psoriasis arthritis and psoriasis had increased risk for:
- Hashimoto’s thyroiditis: aHR, 2.09 (95% CI, 1.34-3.24) and 1.47 (95% CI, 1.18-1.82), respectively;
- Grave’s disease: aHR, 1.38 (95% CI, 1.07-1.79) and 1.26 (95% CI, 1.13-1.41), respectively;
- thyroiditis: aHR, 2.05 (95% CI, 1.51-2.77) and 1.42 (95% CI, 1.22-1.64), respectively;
- incident hypothyroidism: aHR, 1.74 (95% CI, 1.34-2.27) and 1.38 (95% CI, 1.23-1.56), respectively;
- incident hyperthyroidism: aHR, 1.32 (95% CI, 1.07-1.65) and 1.22 (95% CI, 1.11-1.33), respectively.
For further reference log on to https://doi.org/10.1016/j.jaad.2018.11.049