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Prediabetes with fasting blood sugar ≥ 100 mg/dl linked to high blood pressure risk


Prediabetes with fasting blood sugar ≥ 100 mg/dl linked to high blood pressure risk

Prediabetes with fasting blood sugar ≥ 100 mg/dl is independently associated with high Blood Pressure risk.

Fasting blood sugar in the range of prediabetes is independently and significantly associated with future development of high blood pressure hypertension, pointed out a study published in the Journal of Cardiovascular Diabetology.

Prediabetes is a well-established risk factor for progression to overt diabetes mellitus (DM), which is in turn associated with the development of hypertension (HTN) and vice versa. However, the role of prediabetes and HbA1c in particular as an independent risk factor for the development of hypertension is unclear.

The study aimed to evaluate the association between both Fasting blood sugar and hemoglobin A1c (HbA1c) levels in the prediabetes range and development of HTN among a large cohort of normotensive subjects.

In the study, Normoglycemia was defined as HbA1c < 5.7% and Fasting blood sugar < 100 mg/dl. Prediabetes was defined according to the ADA criteria, i.e., 6.5% > HbA1c ≥ 5.7% or impaired fasting blood sugar(IFG):126 mg/dl > Fasting blood sugar ≥ 100 mg/dl.

The authors investigated 5016 normotensive participants without DM and other cardiovascular risk factors who were annually screened in a tertiary medical centre. Subjects were divided into normoglycemic and prediabetic groups. Subgroup analysis was made by dividing participants into four groups according to FPG and HbA1C levels, i.e., normoglycemia, impaired HbA1c only, IFG only, and both parameters impaired.

The authors found that 318 subjects developed HTN. A cumulative hazard function for the development of hypertension showed a 2.89-fold increased risk for HTN in the prediabetic population. In a multivariable Cox proportional hazard regression model adjusted to common confounding risk factors for HTN, prediabetes was found to be independently associated with a 1.95-fold increased risk for hypertension. Impaired HbA1C only was not found to be independently associated with HTN, while IFG only showed a 2.13-fold increased risk for HTN compared to normoglycemic, and a 2.55-fold increased risk for HTN when both parameters impaired.

The study demonstrated that Fasting blood sugar in the prediabetes range, albeit not glycated hemoglobin, is independently and significantly associated with future development of high blood pressure. The authors feel that their findings further highlight the pivotal predictive role of Fasting blood sugar for HTN development as opposed to the limited independent role of abnormal HbA1c levels.

To know more about the study

https://doi.org/10.1186/s12933-019-0859-4

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Source: self

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  1. High Sugar causes inflammation of the blood vessels thereby leading to High BP ..possible cause , experts ?

  2. user
    Priya Ranjan May 5, 2019, 3:32 am

    An informative article. Seems technology is so advance now instead of worrying about disease like diabetes we can use FreeStyle Libre Pro sensor from Abbott with Ambrosia Systems NightRider/ BluCon to see glucose readings on phone and smart watch. Readings updates every 5 minutes so we can find out what food we should avoid to control our sugar levels

  3. All readers, like me, you must\’ve reached the comments section after reading the article. Please, completely erase this article from your mind. Forget that you\’ve ever read it. Don\’t get into the hype of the no. 100, for fasting sugar. Just ignore.

  4. user
    Dr J N Naidu May 4, 2019, 9:20 pm

    Prediabetes should considered as an alarm and lifestyle changes including dietary changes should be initiated and patient should get counseling about the problems he will face if lifestyle changes are not followed.Medication should be avoided for prediabetes .

  5. user
    Vineet agrawal May 4, 2019, 8:12 pm

    Please don\’t create panic instead of creating awareness by setting the lower limit of blood sugar to 100 and start advocating side effects beyond 100..