This site is intended for Healthcare professionals only.

Parkinson’s disease cure closer with Palmitoylethanolamide


Parkinson’s disease cure closer with Palmitoylethanolamide

Washington : A team of researchers has brought a cure for Parkinson’s disease closer to reality.

Palmitoylethanolamide, an endogenous fatty acid amide signalling molecule well-known for its ability to promote the resolution of neuro inflammation and exert neuroprotection, has shown potential therapeutic action in such animal models.

The research showed that ultra-micronized palmitoylethanolamide (um-PEA), slows down disease progression and disability when used as add-on therapy in advanced PD patients.

30 patients with diagnosed PD (mean age of 73) receiving L-DOPA daily and other PD medications in some cases were assessed monthly over 3 consecutive months. Thereafter, um-PEA (Normast, a food for special medical purposes) was given at 1200 mg daily for 3 months, followed by 600 mg/day for up to 12 months.

The MDS-UPDRS questionnaire was used to assess motor and non-motor symptoms. Patients underwent clinical assessment at months 1, 3, 6 and 12. PD medications were maintained during the period of um-PEA treatment.

The um-PEA add-on therapy to L-DOPA led a significant and progressive reduction of total score in Non-Motor Aspects of Experiences of Daily Living, decreasing from 9.7 ± 1.18 at baseline to 4.5 ± 0.69 at month 12.

Moreover, one year um-PEA adjuvant therapy brought about a significant and progressive reduction in the average Motor Aspects of Experiences of Daily Living total score, from 12.7 ± 1.37 at baseline to 7.6 ± 1.06 at month 12.

In addition, average total motor complication score diminished from 8.8 ± 0.8 at baseline to 4.2 ± 0.48 after 12 months of um-PEA adjuvant therapy.

The addition of um-PEA treatment also induced a significant and progressive reduction of motor complications that went from 8.8 ± 0.8 at baseline to 4.2 ± 0.48 at the end of um-PEA therapy.

None of the participants reported side effects attributable to um-PEA.

In conclusion, um-PEA represents a safe and efficacious adjuvant treatment in patients with advanced PD receiving L-DOPA therapy, by providing clinically meaningful improvements in non-motor and motor aspects of daily living, as well as motor symptoms and motor complications of the disease. Moreover, our findings demonstrate the translatability of um-PEA action in PD from rodent to man.

The study is CNS & Neurological Disorders Drug Targets.

The following two tabs change content below.
supriya kashyap

supriya kashyap

Supriya Kashyap Joined Medical Dialogue as Reporter in 2015 . she covers all the medical specialty news in different medical categories. She also covers the Medical guidelines, Medical Journals, rare medical surgeries as well as all the updates in medical filed. She is a graduate from Delhi University. She can be contacted at supriya.kashyap@medicaldialogues.in Contact no. 011-43720751
Source: ANI

Share your Opinion Disclaimer

Sort by: Newest | Oldest | Most Voted
  1. I am 56 years of age and was quickly diagnosed with Parkinson\’s 11 months ago. My symptoms are shakiness (increasing) and general reduction of control and strength of the left hand. I experienced a general tightness of the chest accompanied by periodic sudden feelings of shortness of breath. I also become quite dizzy when performing any athletic function (jogging). I was quite active . I was on Levodopa/Carbidopa, 100/25.i spent a lot of money on medication,so i decided search for permanent cure.
    One faithful day on the internet I saw some post\’s about perfecthealthherbalmedicinehome,so many people was talking about their herbal medicine that they cures different kinds of deadly diseases,so i decided to give it a try ,i contacted them via their email,(perfecthealthherbalmedicine gmail com) website;(www perfecthealthherbal weebly com),so they replied me,and told me that they will cure me within 5-6 weeks ,then i purchased the herbal medicine and they sent the herbal medicine to me via courier service,which i received within 2days.so after 5 weeks of usage all my symptoms disappeared totally ,then i went for medical check-up and doctor confirmed i am totally cured and parkinson\’s diseases free.so please viewers my testimony is a true life story,all thanks to perfecthealthherbalmedicinehome…

    Best Regards