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Oxaceprol, good alternative to NSAIDs for osteoarthritis patients

Oxaceprol, good alternative to NSAIDs for osteoarthritis patients

Bengaluru, India: Oxaceprol may be a good alternative to commonly prescribed non-steroidal anti-inflammatory drugs (NSAIDs) for the long-term management of osteoarthritis (OA), imply results from a latest systematic review and meta-analysis published in the journal Pharmacological Reports. Oxaceprol has similar efficacy and better safety and tolerability compared with NSAIDs.

Sharanbasappa Durg, Real World Evidence, Molecular Connections (P) Ltd., Basavanagudi, Bengaluru, India, and colleagues conducted a  meta-analysis of 7 randomised controlled trials (RCTs; n=1087) to evaluate the efficacy, safety and tolerability of oxaceprol (200 or 400 mg; three times in a day [tid]) monotherapy or in combination compared with active control group such as NSAIDs (diclofenac or ibuprofen) or placebo for varying durations (20-152 days). They then assessed pain and function of joint, quality of life, efficacy, safety, and tolerability. 

“Given the nature of small-to-moderate sample size and short duration of eligible studies, the available clinical evidence of oxaceprol in the management of OA is modest – though looks promising,” write the authors.

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Also Read: Beware: Tramadol Associated with more deaths in osteoarthritis, says JAMA

Key Findings:
  • Compared with active control (diclofenac/ ibuprofen), oxaceprol demonstrated numerically better improvement in the Lequesne joint function index.
  • Oxaceprol was as effective as active control in improving pain relief at rest and weight-bearing pain relief, showed similar improvement vs active control in global treatment efficacy (oxaceprol: 47.0-73.4%vs diclofenac/ibuprofen: 56.0-63.3%).
  • Oxaceprol showed significant improvement in pain and joint function as compared to placebo.
  • Numerically less adverse events were reported when treated with oxaceprol compared with active control and significantly fewer adverse events compared with placebo.

Also Read: New drug discovered to treat diet-induced osteoarthritis

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“Oxaceprol promises to be a good alternative to commonly prescribed NSAIDs for long-term management of patients with OA. However, additional well-designed RCTs with large sample and longer follow-up are required to generate thorough evidence to strengthen the results,” concluded the authors.
For further reference log on to 10.1016/j.pharep.2018.12.010

Source: With inputs from Pharmacological Reports

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    Dr Ramesh vardhan March 18, 2019, 12:54 pm

    There is hardly any thing in supportive of of pain reduction mechanism in this article. It more of comparative study between the diclofenac & oxaceprol. Oxaceprol neither a analgesic or an anti-inflammatory drug. Therefore the comparison itself looks irrelevant.