Bengaluru, India: Oxaceprol may be a good alternative to commonly prescribed non-steroidal anti-inflammatory drugs (NSAIDs) for the long-term management of osteoarthritis (OA), imply results from a latest systematic review and meta-analysis published in the journal Pharmacological Reports. Oxaceprol has similar efficacy and better safety and tolerability compared with NSAIDs.
Sharanbasappa Durg, Real World Evidence, Molecular Connections (P) Ltd., Basavanagudi, Bengaluru, India, and colleagues conducted a meta-analysis of 7 randomised controlled trials (RCTs; n=1087) to evaluate the efficacy, safety and tolerability of oxaceprol (200 or 400 mg; three times in a day [tid]) monotherapy or in combination compared with active control group such as NSAIDs (diclofenac or ibuprofen) or placebo for varying durations (20-152 days). They then assessed pain and function of joint, quality of life, efficacy, safety, and tolerability.
“Given the nature of small-to-moderate sample size and short duration of eligible studies, the available clinical evidence of oxaceprol in the management of OA is modest – though looks promising,” write the authors.
- Compared with active control (diclofenac/ ibuprofen), oxaceprol demonstrated numerically better improvement in the Lequesne joint function index.
- Oxaceprol was as effective as active control in improving pain relief at rest and weight-bearing pain relief, showed similar improvement vs active control in global treatment efficacy (oxaceprol: 47.0-73.4%vs diclofenac/ibuprofen: 56.0-63.3%).
- Oxaceprol showed significant improvement in pain and joint function as compared to placebo.
- Numerically less adverse events were reported when treated with oxaceprol compared with active control and significantly fewer adverse events compared with placebo.
Medha Baranwal joined Medical Dialogues as a Desk Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University.
She can be contacted at email@example.com.
Contact no. 011-43720751