Oxaceprol, good alternative to NSAIDs for osteoarthritis patients

Written by Medha Baranwal Baranwal Published On 2019-03-15T20:20:08+05:30 | Updated On 12 Aug 2021 3:41 PM IST

Bengaluru, India: Oxaceprol may be a good alternative to commonly prescribed non-steroidal anti-inflammatory drugs (NSAIDs) for the long-term management of osteoarthritis (OA), imply results from a latest systematic review and meta-analysis published in the journal Pharmacological Reports. Oxaceprol has similar efficacy and better safety and tolerability compared with NSAIDs.

Sharanbasappa Durg, Real World Evidence, Molecular Connections (P) Ltd., Basavanagudi, Bengaluru, India, and colleagues conducted a meta-analysis of 7 randomised controlled trials (RCTs; n=1087) to evaluate the efficacy, safety and tolerability of oxaceprol (200 or 400 mg; three times in a day [tid]) monotherapy or in combination compared with active control group such as NSAIDs (diclofenac or ibuprofen) or placebo for varying durations (20-152 days). They then assessed pain and function of joint, quality of life, efficacy, safety, and tolerability.

"Given the nature of small-to-moderate sample size and short duration of eligible studies, the available clinical evidence of oxaceprol in the management of OA is modest – though looks promising," write the authors.

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Key Findings:

Compared with active control (diclofenac/ ibuprofen), oxaceprol demonstrated numerically better improvement in the Lequesne joint function index.

Oxaceprol was as effective as active control in improving pain relief at rest and weight-bearing pain relief, showed similar improvement vs active control in global treatment efficacy (oxaceprol: 47.0-73.4%vs diclofenac/ibuprofen: 56.0-63.3%).

Oxaceprol showed significant improvement in pain and joint function as compared to placebo.

Numerically less adverse events were reported when treated with oxaceprol compared with active control and significantly fewer adverse events compared with placebo.

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"Oxaceprol promises to be a good alternative to commonly prescribed NSAIDs for long-term management of patients with OA. However, additional well-designed RCTs with large sample and longer follow-up are required to generate thorough evidence to strengthen the results," concluded the authors.

For further reference log on to 10.1016/j.pharep.2018.12.010

diclofenacibuprofenNon-steroidal anti-inflammatory drugsNSAIDsosteoarthritisoxaceprolPharmacological Reports

Source : With inputs from Pharmacological Reports

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Medha Baranwal Baranwal