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Ovary removal increases risk of CKD among Premenopausal women


Ovary removal increases risk of CKD among Premenopausal women

According to a new Mayo Clinic study, Ovary removal may increase the risk of chronic kidney disease, CKD among Premenopausal women. The study has been published in the Clinical Journal of the American Society of Nephrology.

An estimated 30 million adults in the U.S. have chronic kidney disease, and it is the ninth leading cause of death in the U.S., according to the Centers for Disease Control and Prevention. Chronic kidney disease, also known as chronic kidney failure, implies that a  person’s kidneys are damaged and are therefore unable to filter blood the way that they should. In case an individual’s kidney becomes severely damaged and starts to fail, treatment options are limited to dialysis and a kidney transplant.

Previous studies conducted on animals have shown that the female hormone estrogen protects the kidneys. That led Mayo Clinic researchers to wonder how removing both ovaries would affect kidney function in premenopausal women.

The researchers used the records-linkage system of the Rochester Epidemiology Project and compared 1,653 premenopausal women living in Olmsted County, Minnesota, who had their ovaries surgically removed prior to 50 to an equal number of women of similar ages who did not have their ovaries removed. The women were followed for a median of 14 years. Mayo Clinic researchers found that women who had their ovaries removed had a 6.6 percent higher risk of developing chronic kidney disease, compared to those who did not. The risk of kidney failure was even higher for women younger than 46. Those who had their ovaries removed before 46 had a 7.5 percent increased risk of chronic kidney disease.

“This is the first study that has shown an important link between estrogen deprivation in younger women and kidney damage. Women who have their ovaries surgically removed have an increased long-term risk of chronic kidney disease,” says Walter Rocca, M.D., a Mayo Clinic neurologist and epidemiologist, and senior author.

These results highlight the need for physicians to discuss the potential increased risk for chronic kidney disease with women considering having their ovaries removed, according to Dr. Rocca.

“For women who do not have an increased genetic risk for breast and ovarian cancer, we recommend against the removal of the ovaries as a preventive option due to the increased risk of diseases, including chronic kidney disease and the increased risk of death,” Dr. Rocca says.

Source: With inputs from Clinical Journal of the American Society of Nephrology

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  1. It is true. Endogenous sex hormones, and specifically estradiol, appear to be renoprotective in women, although the effects of exogenous estradiol (as an oral contraceptive and postmenopausal hormone therapy) on kidney function are more controversial. The selective estrogen receptor modulator raloxifene has been associated with both a decreased fracture risk as well as renoprotection in women with kidney disease. Young women with ESKD are more likely to die from infection or develop malignancy, suggesting an immunomodulatory role of estrogen.