One third of severe asthma patients using harmful doses of oral steroids,finds a Netherlands study

A third of patients with severe asthma are taking harmful doses of oral steroids, according to a study of several thousand people in The Netherlands, presented at the European Respiratory Society International Congress. The serious adverse events faced by asthma patients taking maintenance or rescue oral corticosteroids (OCS) might be avoidable if data from the study is considered seriously.

There is a great risk of serious side effects of oral steroids such as diabetes, osteoporosis and adrenal insufficiency, in which the adrenal glands do not produce adequate amounts of steroid hormones if Asthma patients keep using high doses of oral steroids.

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The majority of these patients could avoid taking oral steroids by improving their adherence to their other asthma medication and their inhaler technique, Dr Katrien Eger told the congress. However, there remains a proportion who might be eligible for treatment with new biologic asthma drugs, yet only half are receiving them.

"Our findings show that many patients with severe asthma are taking harmfully high doses of oral steroids. Every prescription for oral steroids should alert doctors to assess adherence to inhaled therapies and inhalation techniques in these patients. Furthermore, now that there is an increasing number of biologic asthma drugs available that avoid the need for oral steroids, doctors should initiate biologic treatment in suitable patients to reduce exposure to harmful oral steroids."

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In this study, 5,002 patients on high doses of inhaled corticosteroids (ICS), defined as at least 500 mcg/day, were identified in a pharmacy database in the Netherlands. These patients were asked to complete a questionnaire to determine how many had severe asthma and had received rescue or maintenance OCS in the past year.Dr Eger and her colleagues analysed information from a pharmacy database of 500,500 Dutch inhabitants to identify patients who were using high doses of inhaled corticosteroids (500 micrograms or more a day) plus long-acting beta agonists, and who were identified as having severe asthma according to the Global Initiative for Asthma (GINA). The database also contained information on oral steroid use (cortisone). The researchers sent questionnaires to 5002 of these patients and then analysed the 2312 that were returned. Information from the pharmacy database enabled them to collect information on oral steroid use and adherence to medication. Pharmacists assessed inhaler technique in a sample of the patients.

The questionnaire asked about medical history, including any other medical conditions, asthma diagnosis and control, and smoking history. If prescriptions were completed 80% or more of the time, the patients were considered to be adherent to their medication.

"We found that 29% of asthma patients who were using high doses of inhaled steroids were also taking harmfully high doses of oral steroids of 420 milligrams a year or more," said Dr Eger. Of these patients, 78% had poor adherence to inhaled medication or incorrect inhalation technique. So these problems should be tackled first in these patients before considering biologic treatment. The remaining 22% are candidates for biologic drugs.

"If we extrapolate our results from the database to the general Dutch population, this would mean that there are about 6000 patients with severe asthma who are candidates for biologic treatment - 1.5% of the whole asthma patient population. But less than half - 46% - are currently receiving it. This shows that there is potential to substantially reduce oral steroid overuse."

Dr Eger said her research did not show why so many patients were overusing oral steroids and so few were receiving biologic treatments, but reasons could be that patients don't consult their doctors and that, when they do, the doctors don't assess them thoroughly or don't identify them as being candidates for biologic treatment.

Although biologic treatments, such as omalizumab, mepolizumab, reslizumab, benralizumab and dupilumab, are expensive, identifying and treating patients who could benefit from them would have economic benefits, said Dr Eger.

"If they reduce exposure to harmful oral steroids and thus reduce the adverse effects, this could lead to a reduction in the cost of healthcare. Another important way to look at this is that patients can exercise more and experience fewer exacerbations of their disease, and so have fewer days off work due to illness."

The proportion of asthma patients who do not adhere to their inhaler medication or have poor inhaler technique is likely to be similar in other countries. However, access to biologic treatment may vary between countries.

"In The Netherlands, we have very good access to health care and biologics are available to anyone who needs them. Unfortunately, this is not the case in every part of the world," said Dr Eger.

Research shows that a lifetime, cumulative dose of between 0.5-1 grams of oral steroids is associated with adverse side effects. The risk increases with increasing doses.

Professor Guy Brusselle, from Ghent University, Belgium, is Chair of the European Respiratory Society Science Council and was not involved in the study. He said: "Oral corticosteroids are an important medication for acute treatment of moderate to severe asthma flare-ups; they reduce inflammation in patients' airways during acute exacerbations to make it easier to breathe again, thereby helping to reduce the risk of hospitalisation. However, we know that overuse of oral steroids, such as frequent courses or chronic use, will harm patients' health over the long-term, as these medications have many side effects.

"Alternative treatments such as biologic drugs may offer one way to reduce long-term use of oral corticosteroids, but supporting patients to improve their inhaler technique and adherence to other asthma medications, mainly inhalers, will limit the need for use of oral corticosteroids and help to better protect the overall health of asthma patients.