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Obstructive sleep apnea associated with high LDL Cholesterol

Obstructive sleep apnea associated with high LDL Cholesterol
Obstructive sleep apnoea (OSA) and dyslipidemia are independent risk factors for cardiovascular disease. Ludger Grote, Sleep and Vigilance Laboratory, Sahlgrenska Academy, Gothenburg, Sweden, and colleagues conducted the study to investigate the association between OSA and plasma lipid concentrations in patients enrolled in the European Sleep Apnea Database (ESADA) cohort.
The cross‐sectional analysis included 8592 patients without physician‐diagnosed hyperlipidemia or reported intake of a lipid‐lowering drug (age 50.1 ± 12.7 years, 69.1% male, BMI: 30.8 ± 6.6 kg/m2, mean apnoea-hypopnoea index (AHI): 25.7 ± 25.9 events/h).
The independent relationship between measures of OSA (AHI, oxygen desaturation index (ODI), mean and lowest oxygen saturation) and lipid profile (total cholesterol (TC), high‐density lipoprotein cholesterol (HDL‐C), low‐density lipoprotein cholesterol (LDL‐C) and fasting triglycerides (TG)) was determined by means of general linear model analysis.
Key Results:
  • There was a dose-response relationship between TC and ODI.
  • TG and LDL concentrations were better predicted by AHI than by ODI.
  •  HDL‐C was significantly reduced in the highest AHI quartile.
  • Morbid obesity was associated with lower TC and higher HDL‐C values.
  • Lipid status was influenced by geographical location with the highest TC concentration recorded in Northern Europe.

“Our data clearly suggest that sleep apnoea may have a negative impact on lipid levels, which may in part explain the association between sleep apnoea and increased risk for cardiovascular disease,” said Dr. Grote. “Patients with sleep apnea, therefore, need careful management of all cardiovascular risk factors including hyperlipidemia.”

“Our results demonstrate that OSA severity was independently associated with cholesterol and TG concentrations,” concluded the authors.

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Source: With inputs from Respirology

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