This site is intended for Healthcare professionals only.

Now, Multicolor MRIs for diagnosis of diseases


Now, Multicolor MRIs for diagnosis of diseases

Researchers at Case Western Reserve University School of Medicine have developed a method that could make magnetic resonance imaging MRI multicolor. Current MRI techniques rely on a single contrast agent injected into a patient’s veins to vivify images. The new method uses two at once, which could allow doctors to map multiple characteristics of a patient’s internal organs in a single MRI. The strategy could serve as a research tool and even aid disease diagnosis.

“The method we developed enables, for the first time, the simultaneous detection of two different MRI contrast agents,” said Chris Flask, PhD, Associate Professor of Radiology, Biomedical Engineering, and Pediatrics, and Director of the Imaging Resource Core at Case Western Reserve University School of Medicine. Two contrast agents could include one specifically targeting diseased tissue, and one designed to show healthy tissue, for example. The new method would enable immediate comparisons of how each agent distributes in the same patient.

“This multi-agent detection capability has the potential to transform molecular imaging, as it provides a critical translational pathway for studies in patients,” said Flask. It also provides a unique imaging platform to rigorously study molecular therapies.” Therapies could include those targeting biomarkers or other detectable molecules associated with diseases.

Flask and colleagues recently described their new method in Scientific Reports. The paper describes how two contrast agents, gadolinium and manganese, can be detected and independently quantified during MRIs. The authors span 11 departments at Case Western Reserve, uniting engineers, nurses, clinicians, and basic science researchers. They also include several members of the Case Comprehensive Cancer Center. According to the authors, their results provide “an adaptable, quantitative imaging framework to assess two MRI contrast agents simultaneously for a wide variety of imaging applications.”

The researchers have begun to investigate widespread practical applications for the new MRI approach. Said Flask, “In this initial paper, we validated our new methodology, opening the possibility for numerous follow-on application studies in cancer, genetic diseases such as cystic fibrosis, and metabolic diseases such as diabetes.”

You can read the full Article by clicking on the link :

Christian E. Anderson, Shannon B. Donnola, Yun Jiang, Joshua Batesole, Rebecca Darrah, Mitchell L. Drumm, Susann M. Brady-Kalnay, Nicole F. Steinmetz, Xin Yu, Mark A. Griswold, Chris A. Flask. Dual Contrast – Magnetic Resonance Fingerprinting (DC-MRF): A Platform for Simultaneous Quantification of Multiple MRI Contrast AgentsScientific Reports, 2017; 7 (1) DOI: 10.1038/s41598-017-08762-9

The following two tabs change content below.
supriya kashyap

supriya kashyap

Supriya Kashyap Joined Medical Dialogue as Reporter in 2015 . she covers all the medical specialty news in different medical categories. She also covers the Medical guidelines, Medical Journals, rare medical surgeries as well as all the updates in medical filed. She is a graduate from Delhi University. She can be contacted at supriya.kashyap@medicaldialogues.in Contact no. 011-43720751
Source: self

Share your Opinion Disclaimer

Sort by: Newest | Oldest | Most Voted