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    • Now Fecal transplant...

    Now Fecal transplant by oral capsule to prevent Clostridium difficile infection

    Written by Anjali Nimesh Nimesh Published On 2017-11-30T19:05:19+05:30  |  Updated On 30 Nov 2017 7:05 PM IST
    Now Fecal transplant by oral capsule  to prevent Clostridium difficile infection

    Why The Research Is Interesting: Clostridium difficile infection (CDI) causes inflammation of the colon and severe diarrhea. The infection occurs when normal gut bacteria are disrupted. Fecal transplants to re-establish normal gut bacteria are the most effective treatment for preventing CDI in people who have already had the infection. Giving the treatment by a pill would save time and cost relative to giving the treatment by colonoscopy if the two treatments were no different.


    Who and When: 116 patients with recurrent CDI enrolled from October 2014 to September 2016 and followed through 2016.


    What (Study Measures):


    Exposure: Patients were nearly evenly divided to receive a fecal transplant using a capsule or colonoscopy.


    Outcome: Number of recurrent CDIs 12 weeks after fecal transplant.


    How (Study Design): This was a noninferiority randomized clinical trial (RCT). Noninferiority RCTs are designed to assess whether one treatment (in this case capsule-based fecal transplant) was "no worse" than a comparison treatment (colonoscopy-based fecal transplant).


    Authors: Dina Kao, M.D., F.R.C.P.C., of the University of Alberta, Edmonton, Canada, and coauthors.


    Results: Recurrent CDI was prevented after a single treatment in 96 percent of patients in both groups after 12 weeks; more patients who received capsules rated their experience as "not at all unpleasant."


    Study Limitations: Patients with severe and complicated CDI were excluded, so the findings may not apply to those cases.


    Study Conclusions: Fecal transplant using oral capsules may be as effective as colonoscopy to prevent recurrent CDI.

    CDIClostridium difficile infectioncolonoscopydiarrheaFecal transplantGut Bacteriainfectionoral capsulessevere diarrheaUniversity of Alberta
    Source : Eureka Alert

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    Anjali Nimesh Nimesh
    Anjali Nimesh Nimesh
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