Nice guidelines 2016 on clot removal in stroke patients

A stroke occurs when the normal blood supply to part of the brain is cut off. This starves the brain cells of oxygen in the area affected, causing them to become damaged or die. An ischaemic stroke is a stroke that can be caused by a blood clot blocking an artery supplying the brain. Symptoms may include problems with speech and balance, and weakness on one side of the body.

The current mainstay of treatment for ischaemic stroke is the use of drugs as soon as possible after the stroke to dissolve the blood clot (thrombolysis). However, these must be given within 4.5 hours of the start of the stroke and only benefit around 1 in 7 people treated.

Mechanical clot retrieval can be used for blockages in large blood vessels. The patient first has cerebral angiography (a procedure using dye and X-rays that shows how blood flows through the arteries in the neck and brain) to see where the blood clot is. With the patient under sedation and local anaesthetic or under general anaesthetic, a catheter is inserted through a large blood vessel, usually in the groin, and moved forward to get pictures of the brain’s blood supply. The clot removal device is inserted through the catheter and positioned near the site of the clot.

Different devices and methods have been used to remove blood clots, but the most commonly used one is called a stent retriever, which traps and removes clots. The aim is to remove the clot as soon as possible, within a few hours of the stroke.

Mirella Marlow, Programme Director – Device and Diagnostics Systems at NICE, says: “In England, approximately 110,000 people have a stroke each year. It’s the fourth single largest cause of death and is the largest cause of complex disability, with limited available treatments. We are therefore pleased to be able to recommend normal arrangements for this procedure.

“When we originally looked at this in 2013 there was not enough evidence for us to advise that it worked well enough and was safe enough.

“At the time, we encouraged clinicians to collect more data to provide us with further evidence of the procedure’s long-term safety and effectiveness. We’re pleased that specialists took notice of our recommendation and recorded this information – this has contributed to NICE now being able to recommend this procedure with normal arrangements for clinical governance, consent and audit.

“We will also be exploring the potential for further NICE guidance on the devices used in the procedure.”

The NICE guidance on mechanical clot retrieval for treating acute ischaemic stroke in adults is available on the following link:

NICE guidance on mechanical clot retrieval for treating acute ischaemic stroke