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New simple,accurate Test for faster detection of Rabies

New simple,accurate Test for faster detection of Rabies

The  Centers for Disease Control and Prevention (CDC) has developed a new simple rabies test for faster detection of disease .This may  help people exposed to potentially rabid animals  forego the treatment regimen of injections spread over weeks for prevention from the deadly disease.The new test  can accurately and  precisely diagnose rabies infection  in animals and allow doctors and patients to make better informed decisions about who needs treatment for rabies.The study pertaining to the new test has been  published  in PLOS One.

The current gold-standard for rabies testing in animals is the direct fluorescent antibody (DFA) test, which can only be interpreted by laboratory workers with special skills, extensive training, and a specific type of microscope.But the new test has several advantages like:

  • The new LN34 test is simpler and easier to use than present available tests.
  • The LN34 test proved nearly 100 percent accurate.
  • During the pilot study, it produced no false negatives, fewer false positive, and fewer inconclusive results.
  • It  can also be run on testing platforms already widely used in the U.S. and worldwide for the flu, tuberculosis, and HIV.
  • It does not require  any extra training for the personnel.
  • It yields results  from fresh, frozen, or  decomposing animal brain tissue.

The new test could revolutionise  rabies testing in  resource-poor countries. Currently, testing facilities in many countries are dismal so knowing if an animal that bit someone is rabid is valuable information.

In the recent study, staff at 14 labs worldwide assessed nearly 3,000 animal brain samples from the Americas, Europe, Africa, and Asia, of which more than 1,000 were known to be infected with rabies virus. The samples came from more than 60 mammal species that get rabies, including dogs, raccoons, skunks, foxes, and bats.

This study is the largest ever to validate usage of a real-time RT-PCR test to diagnose rabies in animals.The new test  could  not only save lives but could also prevent dog bite victims  from  unnecessary injections.

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Source: self

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  1. the test is developed to detect Rabies in animal brain tissue.
    In India , this is so impractical as you cannot kill a dog if it has bitten someone unless it dies on its own. Besides dog bites normally occur in stray population and you may not catch hold of the dog everytime. Precious time is lost between initiating the treatment and the dog bite. So better initiate the treatment and if possible observe the dog if available.

  2. user
    Dr Devendra Singh Thakur May 18, 2018, 3:45 pm

    Research about rabies is very dificult because of low prevalance.Any research about rabies should be considerd as topmost work for humanity