Nerve growth factor signals through receptors of the tropomyosin-related kinase (Trk) family and research in animals has shown that inhibitors of Trks A, B, and C can reduce pain. Now a new study in the British Journal of Clinical Pharmacology provides the first demonstration of pain relief in humans using a Trk inhibitor.
The inhibitor was compared with pregabalin, ibuprofen, and placebo, in randomized, double-blind, cross-over study with 20 participants.
“One striking aspect of this study is the use of a pain challenge model to assess this novel Trk mechanism. By determining the effect of a single dose of the drug in healthy subjects, we were able to provide an early demonstration of analgesia without the need to run a large patient study,” said lead author Dr. Peter Loudon, of Pfizer WRD, in the UK. “Furthermore, the use of a range of different pain challenge models has provided some information on the quality of effect, which may help predict the best patient population for future studies.”
For more details click on the link: http://dx.doi.org/10.1111/bcp.13448