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New drug sak3 may offer hope to Alzheimer’s disease patients


New drug sak3 may offer hope to Alzheimer’s disease patients

Acetylcholine is a neurotransmitter in the brain that plays an important role in controlling attention and cognition. Acetylcholine system dysfunction is believed to be one of the causes of Alzheimer’s disease (AD) and vascular dementia.

Now, a new drug that could treat Alzheimer’s disease, SAK3, has been developed by a Japanese research group led by Tohoku University Professor Kohji Fukunaga.

In their study, the researchers found that the T-type calcium channel enhancer, SAK3, stimulates the release of acetylcholine in the brain and improves cognition by activating the memory molecule CaMKII. According to Professor Fukunaga, SAK3 also reduces the production of amyloid beta protein in the study’s model mice. This, he says, could lead to the development of the first disease-modifying drug to prevent mild to severe Alzheimer disease.

SAK3 is now in the preclinical stage of drug development, and has so far proven to be safe and well-tolerated in animal experiments. Clinical trials are expected to begin in the next few years.

You can read the full Article by clicking on the link :

Yasushi Yabuki, Kazuya Matsuo, Hisanao Izumi, Hidaka Haga, Takashi Yoshida, Minoru Wakamori, Akira Kakehi, Kenji Sakimura, Takaichi Fukuda, Kohji Fukunaga. Pharmacological properties of SAK3, a novel T-type voltage-gated Ca2 channel enhancer. Neuropharmacology, 2017; DOI: 10.1016/j.neuropharm.2017.01.011

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supriya kashyap

supriya kashyap

Supriya Kashyap Joined Medical Dialogue as Reporter in 2015 . she covers all the medical specialty news in different medical categories. She also covers the Medical guidelines, Medical Journals, rare medical surgeries as well as all the updates in medical filed. She is a graduate from Delhi University. She can be contacted at supriya.kashyap@medicaldialogues.in Contact no. 011-43720751
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