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New compound may help fight epilepsy


New compound may help fight epilepsy

A team of researchers have developed neuro protective compounds that may help prevent the development of epilepsy in humans.

Epilepsy is a disorder in which nerve cell activity in the brain is disturbed, causing seizures.

Researchers from Louisiana State University in the US, discovered and patented the compounds known as LAU that prevented the seizures and their damaging effects on dendritic spines in an experimental model of epilepsy in mice.

“In the study, preservation of dendritic spines and subsequent protection from seizures, were observed up to 100 days post-treatment, suggesting the process of epilepsy development has been arrested,” said professor Nicolas Bazan.

These compounds were found to act by blocking a neuro-inflammatory signalling receptor, which results in the protection of dendritic spines.

LAU compounds also lessened seizure susceptibility and onset, as well as hyper excitability of brain circuits known to cause seizures.

“Most of the anti-epileptic drugs currently available treat the symptom ┬áseizures not the disease itself. Understanding the potential therapeutic usefulness of compounds that may interrupt the development process may pave the way for disease-modifying treatments for patients at risk for epilepsy,” informed Bazan.

The results were published in the journal Scientific Reports.

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supriya kashyap

supriya kashyap

Supriya Kashyap Joined Medical Dialogue as Reporter in 2015 . she covers all the medical specialty news in different medical categories. She also covers the Medical guidelines, Medical Journals, rare medical surgeries as well as all the updates in medical filed. She is a graduate from Delhi University. She can be contacted at supriya.kashyap@medicaldialogues.in Contact no. 011-43720751
Source: IANS

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