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Neuroblastoma- Standard Treatment Guidelines


Neuroblastoma- Standard Treatment Guidelines

Introduction

Neuroblastoma is the most common extra cranial solid tumor in children. It arises from neural crest cells which differentiate in cells of the sympathetic ganglia and adrenal medulla. It remains a complex medical challenge with spontaneous regression at one end to an unpredictable clinical course and dismal outcome at the other end of spectrum.

Ministry of Health and Family Welfare, Government of India has issued the Standard Treatment Guidelines for Neuroblastoma.
Following are the major recommendations :

Image defined risk factors (IDRF) for Neuroblastoma

Site of primary tumor: Cervical, cervico-thoracic, thoracic, thoraco-abdominal, abdominal, and pelvic.

Local extent:

  • Crossing midline
  • Encasement of any major vessel at that site like carotid, vertebral, IJV, subclavian, mediastinal great vessels, abdominal aorta and its branches, IVC, iliacs.
  • Infiltration of adjacent critical areas like skull base, trachea, main bronchi, brachial plexus, pericardium, , costo-vertebral junction (especially between D9-D12), portahepatis, hepato-duodenal ligament, mesenteric root, sciatic notch, intra-spinal extension (more than 1/3rd diameter of spinal canal involved on axial image or loss of perimedullary space or abnormal cord).
  • Infiltration of adjacent organs like heart, diaphragm, liver, kidney, spleen, pancreas, etc.

Presence of multifocal primary
Collections in cavities like pleural or peritoneal
Adenopathy: Enlarged local or distant nodes
Metastatic disease: Bony lesions, Liver or lung lesions

Neuroblastoma risk Stratification

  • Risk stratification should be done at a tertiary centre before initiation of therapy.
  • In unresectable lesions generous core biopsy (image guided) should be performed for histopathology and molecular studies.
Risk Age Stage MYCN status
 

Low

<547 days 1, 2A/B,4S NA
> 547 days 1, 2A/B NA
 

 

Intermediate

<547 days 3, 4 NA
> 547 days 3 NA
 

High

<547 days 1, 2, 3, 4, 4S Amp
> 547 days 1,2,3 Amp
 

> 547 days

4 Any

Guidelines by The Ministry of Health and Family Welfare :

Dr Anil K. D’ Cruz
Director and
Chief Head and Neck Services,
Tata Memorial Hospital, Mumbai

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supriya kashyap

supriya kashyap

Supriya Kashyap Joined Medical Dialogue as Reporter in 2015 . she covers all the medical specialty news in different medical categories. She also covers the Medical guidelines, Medical Journals, rare medical surgeries as well as all the updates in medical filed. She is a graduate from Delhi University. She can be contacted at supriya.kashyap@medicaldialogues.in Contact no. 011-43720751
Source: self

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