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Meta analysis contradicts any association of intussusception with rotavirus vaccination
Rotavirus vaccination in infants is not associated with increased risk for intussusception, suggests a meta-analysis in JAMA Network Open.
Rotavirus vaccination is contraindicated in infants with history of intussusception.Threfore Dr Hai long lu and associates conducted the Meta analysis to analyze the association between rotavirus vaccination and risk of intussusception.
In this systematic review and meta-analysis of 25 randomized clinical trials including 200 594 participants (104 647 receiving vaccine and 95 947 receiving placebo) in 33 countries from 4 continents, monovalent, pentavalent, monovalent human-bovine, oral bovine pentavalent, and human neonatal rotavirus vaccinations were not associated with an increased risk of intussusception compared with placebo for up to 2 years after vaccination.
CDC recommends that infants receive rotavirus vaccine to protect against rotavirus disease. Two rotavirus vaccines are currently licensed for use in infants in the United States:
- RotaTeq® (RV5) is given in three doses at 2 months, 4 months, and 6 months of age.
- Rotarix® (RV1) is given in two doses at 2 months and 4 months of age.
The first dose of either vaccine should be given before a child is 15 weeks of age. Also, children should receive all doses of rotavirus vaccine before they turn 8 months old.
Both vaccines are given orally by putting drops in the infant’s mouth.
Contraindications and Precautions for Rotavirus Vaccination
You should not give rotavirus vaccine to babies with:
- a severe (life-threatening) allergic reaction to a previous dose of rotavirus vaccine,
- a severe (life threatening) allergy to any component of rotavirus vaccine,
- severe combined immunodeficiency (SCID), or
- a previous episode of intussusception.
Babies who are mildly ill can get the vaccine. Babies who are moderately or severely ill should wait until they recover. This includes babies with moderate or severe diarrhea or vomiting.
You may consider vaccinating babies with weakened immune systems due to:
- HIV/AIDS, or any other disease that affects the immune system
- treatment with drugs such as steroids
- cancer, or cancer treatment with x-rays or drugs
Conditions commonly misperceived as contraindications for rotavirus vaccine include:
- Prematurity
- Household members who are immunosuppressed
- Household members who are pregnantResearchers examined data from 25 randomized, placebo-controlled trials of five rotavirus vaccines in over 200,000 infants. Most of the trials involved one of the two vaccines licensed in the U.S. — the monovalent vaccine (Rotarix) or the pentavalent vaccine (RotaTeq).
In all 20 cases of intussusception were reported within 31 days after vaccination — 11 with rotavirus vaccine and 9 with placebo. By 1 year, 37 cases had been reported in each group. None of the vaccines was associated with intussusception risk, even at 2 years.
The researchers write, "Our results contradict the postmarketing monitoring suggestion about the risk of intussusception after [rotavirus] vaccination. We suggest that the benefit of the vaccination exceeds the potential risk of intussusception."
For further information log on to:
Association Between Rotavirus Vaccination and Risk of Intussusception Among Neonates and InfantsA Systematic Review and Meta-analysis
JAMA Netw Open. 2019;2(10):e1912458. doi:10.1001/jamanetworkopen.
JAMA Network Open article (Free)
CDC rotavirus vaccine recommendations (Free)
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