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Marijuana smoking linked to higher sperm count, finds study

Marijuana smoking linked to higher sperm count, finds study

According to new research led by Harvard T.H. Chan School of Public Health, men who had ever smoked marijuana had high sperm concentration and count than men who had never smoked marijuana. The study also found that there was no significant difference in sperm concentrations between current and former marijuana smokers. The study will be published in Human Reproduction.

It is estimated that 16.5% of adults in the U.S. use marijuana, and support for legal recreational use of marijuana has increased dramatically in recent years. Understanding the health effects associated with marijuana use is important given the growing perception that it poses few health hazards.

“These unexpected findings highlight how little we know about the reproductive health effects of marijuana, and in fact of the health effects of marijuana in general,” said Jorge Chavarro, associate professor of nutrition and epidemiology at Harvard Chan School. “Our results need to be interpreted with caution and they highlight the need to further study the health effects of marijuana use.”

The researchers hypothesized that marijuana smoking would be associated with worse semen quality. Previous studies on marijuana have suggested that it is associated with negative effects on male reproductive health, but most of those studies had focused on animal models or on men with histories of drug abuse.

For this study, researchers collected 1,143 semen samples from 662 men between 2000 and 2017. On average, the men were 36 years old, and most were white and college educated. Additionally, 317 of the participants provided blood samples that were analyzed for reproductive hormones. To gather information on marijuana use among study participants, researchers used a self-reported questionnaire that asked the men a number of questions about their usage, including if they had ever smoked more than two joints or the equivalent amount of marijuana in their life and if they were current marijuana smokers.

Among the participants, 365, or 55%, reported having smoked marijuana at some point. Of those, 44% said they were past marijuana smokers and 11% classified themselves as current smokers.

Analysis of the semen samples showed that men who had smoked marijuana had average sperm concentrations of 62.7 million sperm per millilitre of ejaculate while men who had never smoked marijuana had average concentrations of 45.4 million sperm per millilitre of ejaculate. Only 5% of marijuana smokers had sperm concentrations below 15 million/mL (the World Health Organization’s threshold for “normal” levels) compared with 12% of men who had never smoked marijuana.

The study also found that among marijuana smokers, greater use was associated with higher serum testosterone levels.

“Our findings were contrary to what we initially hypothesized. However, they are consistent with two different interpretations, the first being that low levels of marijuana use could benefit sperm production because of its effect on the endocannabinoid system, which is known to play a role in fertility, but those benefits are lost with higher levels of marijuana consumption,” said Feiby Nassan, lead author of the study and a postdoctoral research fellow at Harvard Chan School. “An equally plausible interpretation is that our findings could reflect the fact that men with higher testosterone levels are more likely to engage in risk-seeking behaviours, including smoking marijuana.”

Reacting to results of the study, Prof Sheena Lewis, Emeritus Professor of Reproductive Medicine, Queen’s University Belfast, said:

“In studies from our lab in Queens University, Belfast, we found exactly the opposite effects. In subjects, each taking the same moderate dose of marijuana daily over only several weeks, their sperm quality plummeted. Sperm motility decreased, acrosome reactions failed to occur and worst of all, sperm counts dropped and the nurse (Sertoli) cells that help to make sperm disappeared irreversibly.

“I would urge caution in accepting the findings of this study, without further information. Despite its large numbers and authorship from a highly esteemed university, it has several major design flaws: we do not know the baseline of sperm counts before marijuana smoking; making the reported increase less reliable. Secondly, the levels of marijuana taken were just self-reported so are open to high variation. Thirdly, recreational drug users often take cocktails of drugs. Another commonly used recreational drug that impacts on sperm is Viagra. We have reported that Viagra can improve sperm function. Perhaps multi-drug use accounts for these unexpected results.”

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