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    • Magnesium regulates...

    Magnesium regulates Vitamin D levels in body , Trial finds

    Written by Dr. Kamal Kant Kohli Kohli Published On 2018-12-14T20:28:04+05:30  |  Updated On 14 Dec 2018 2:58 PM GMT
    Magnesium regulates Vitamin D levels in body , Trial finds

    Researchers at Vanderbilt-Ingram Cancer Center have found in a randomized trial that magnesium regulates and optimizes vitamin D levels in body. The study reported in the December issue of The American Journal of Clinical Nutrition indicates that Magnesium raises Vitamin D status in people with deficient levels and lowers it in people with high levels.






    The trial confirms an earlier observational study conducted in 2013 wherein the researchers had linked low magnesium levels with low vitamin D levels.This may prevent diseases linked to vitamin D levels especially in wake of ongoing research into the association of vitamin D levels with colorectal cancer and other diseases, including a recent report from the VITAL trial.



    Qi Dai, MD, Ph.D., Ingram Professor of Cancer Research, the study's lead author, described the ideal level as being in the middle range of a U-shape because vitamin D at this level has been linked to the lowest risk of cardiovascular disease in previous observational studies.


    However, vitamin D was not related to cardiovascular disease in the recent VITAL trial. He and Martha Shrubsole, Ph.D., research professor of Medicine, Division of Epidemiology, are investigating the role that magnesium may play with cancer as part of the Personalized Prevention of Colorectal Cancer Trial.


    "There's a lot of information being debated about the relationship between vitamin D and colorectal cancer risk that is based upon observational studies versus clinical trials," Shrubsole said. "The information is mixed thus far."


    They became interested in a role for magnesium because people synthesize vitamin D differently with levels of the vitamin in some individuals not rising even after being given high dosage supplements.


    "Magnesium deficiency shuts down the vitamin D synthesis and metabolism pathway," Dai said.


    The randomized study involved 250 people considered at risk for developing colorectal cancer because of either risk factors or having a precancerous polyp removed. Doses of magnesium and placebo were customized based on baseline dietary intake.


    "Vitamin D insufficiency is something that has been recognized as a potential health problem on a fairly large scale in the U.S.," Shrubsole said. "A lot of people have received recommendations from their health care providers to take vitamin D supplements to increase their levels based upon their blood tests. In addition to vitamin D, however, magnesium deficiency is an under-recognized issue. Up to 80 percent of people do not consume enough magnesium in a day to meet the recommended dietary allowance (RDA) based on those national estimates."


    Shrubsole stressed that the magnesium levels in the trial were in line with RDA guidelines, and she recommended dietary changes as the best method for increasing intake. Foods with high levels of magnesium include dark leafy greens, beans, whole grains, dark chocolate, fatty fish such as salmon, nuts and avocados.


    The trial also revealed something new—that magnesium had a regulating effect in people with high vitamin D levels. The research provides the first evidence that magnesium may play an important role in optimizing vitamin D levels and preventing conditions related to vitamin D levels.

    Colorectal Cancer high levels levels low levels Magnesium deficiency Magnesium role MG optimises regulates Role status Vanderbilt-Ingram Cancer Center vit.D levels 

    Disclaimer: This site is primarily intended for healthcare professionals. Any content/information on this website does not replace the advice of medical and/or health professionals and should not be construed as medical/diagnostic advice/endorsement or prescription. Use of this site is subject to our terms of use, privacy policy, advertisement policy. © 2020 Minerva Medical Treatment Pvt Ltd

    Dr. Kamal Kant Kohli Kohli
    Dr. Kamal Kant Kohli Kohli
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