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Low Birth Weight Ups Type 2 Diabetes Risk

Low Birth Weight Ups Type 2 Diabetes Risk

New York :  Children born with low birth weight due to genetic factors are at increased risk of developing Type 2 diabetes, finds a new study.

The findings showed that the low birth weight was actually causing excess risk in Type 2 diabetes.

“A genetically lowered birth weight was associated with increased susceptibility to Type 2 diabetes,” said Tiange Wang from Tulane University in the US.

Low birth can cause restricted intrauterine growth (foetal growth) a condition in which an unborn baby is smaller than it should be because it is not growing at a normal rate inside the womb.

Further, this restricted foetal growth also represents a risk factor for the low birth weight and in turn causing the Type 2 diabetes.

Risk factors for restricted intrauterine growth include malnutrition, anaemia, infections and placental insufficiency.

“Our findings support a potential causal relation between birth weight and risk of Type 2 diabetes, providing novel evidence to support the role of intrauterine exposures in the pathogenesis of type 2 diabetes,” Wang added.

Evidence from both population and experimental studies has suggested that restricted early life development has long-term structural and functional influence on individuals’ predisposition to an increased risk of metabolic diseases such as Type 2 diabetes, said the paper published in the journal Diabetologia.

The study included 3627 Type 2 diabetes cases and 12,974 controls.

The team created a genetic risk score (GRS) based on five low birth weight-related genetic variations known as single nucleotide polymorphisms (SNPs).

The analysis showed that for each one point increase in GRS (with the score ranging from 1-10), the risk of developing Type 2 diabetes increased by six per cent.

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supriya kashyap

supriya kashyap

Supriya Kashyap Joined Medical Dialogue as Reporter in 2015 . she covers all the medical specialty news in different medical categories. She also covers the Medical guidelines, Medical Journals, rare medical surgeries as well as all the updates in medical filed. She is a graduate from Delhi University. She can be contacted at Contact no. 011-43720751
Source: IANS

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