Long term Vitamin C supplementation improves Diabetes , high BP

A new study has found that long-term Vitamin C supplementation improves Diabetes, high BP. The study published in the journal Diabetes, Obesity and Metabolism has reported that after 4 months of supplementation with Vitamin C, participants with type 2 diabetes (T2D) had a 36% lower daily postprandial glucose and decreased blood pressure (BP) as compared to placebo.

Ascorbic acid (AA) is a major water‐soluble antioxidant that decreases oxidative stress. Oxidative stress has been reported to cause insulin resistance and hyperglycemia-induced diabetes complications. Control of cardio‐metabolic disease risk factors, including high blood pressure, is important in the management of T2D. Systematic reviews of randomized controlled trials have reported potential beneficial effects of Vitamin C supplementation on blood pressure (BP) in individuals with T2D.

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Shaun Mason and associates conducted a double-blind placebo-controlled crossover study to investigate the effects of Vitamin C supplementation on postprandial glucose responses, and on the duration of the time spent in periods of hyper and hypoglycemia.

Thirty-one people with type 2 diabetes were enrolled in a randomized cross-over study involving 4 months of supplementation with oral AA (2x500 mg/day) and placebo. Participants wore continuous glucose monitors for 48 h and consumed standardized meals pre- and post-supplementation. Measurements included postprandial glucose incremental areas under the curve (iAUC), duration of the day in hyper- and hypoglycemia, average 24 h and daily postprandial glucose concentrations, HbA1c, insulin, blood pressure, and oxidative stress.

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The investigators found that following after 4 months of supplementation with AA,( Vitamin C) participants with T2D had a 36% lower daily postprandial glucose iAUC and a − 1.1 mmol/L lower mean post‐prandial glucose concentration as compared to placebo. Improvements in post‐prandial glycemia with AA supplementation likely contributed to the significant decreases also observed in duration of the day spent with hyperglycemia (−2.8 h/d), time spent with post‐prandial hyperglycemia (−1.7 h/d) and average 24‐hour glucose concentration (−0.8 mmol/L) as compared to placebo.

The study concluded that people with type 2 diabetes experienced improved postprandial and 24 h glycemia and decreased blood pressure after 4 months of Ascorbic Acid(Vit C )supplementation when compared to placebo.

FOR full information log on to https://doi.org/10.1111/dom.13571