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LDL-C Treatment Goals as per AACE/ACE Guidelines


LDL-C Treatment Goals as per AACE/ACE Guidelines

These guidelines have been developed by the American Association of Clinical Endocrinologists (AACE) Board of Directors and American College of Endocrinology (ACE) Board of Trustees.It provides guidance on screening, risk assessment, and treatment recommendations for a range of patients with various lipid disorders. All the recommendation are based on a diligent review of the clinical evidence with transparent incorporation of subjective factors and adhere with published AACE protocols for the standardized production of clinical practice guidelines (CPGs).

Atherosclerotic Cardiovascular Disease Risk Categories and LDL-C Treatment Goals as per AACE/ACE Guidelines

These recommendations emphasize the importance of treating low-density lipoprotein cholesterol (LDL-C) in some individuals to lower goals than previously recommended and support the measurement of coronary artery calcium scores and inflammatory markers to help stratify risk. Special consideration is given to patients with diabetes, familial hypercholesterolemia, women, and pediatric patients with dyslipidemia.

Extreme-risk patients: Goals: LDL <55 mg/dL, non-HDL <80 mg/dL, apolipoprotein B (apoB) <70 mg/dL

  • Progressive atherosclerotic cardiovascular disease (ASCVD), including unstable angina, in patients after achieving an LDL-C <70 mg/dL.
  • Established clinical cardiovascular disease in patients with diabetes, chronic kidney disease (CKD) stages 3/4, or heterozygous familial hypercholesterolemia (HeFH).
  • History of premature ASCVD (<55 yr of age in men, <65 in women).
 Very-high-risk patients: Goals: LDL <70 mg/dL, non-HDL <80 mg/dL, apoB <80 mg/dL
  • Established or recent hospitalization for acute coronary syndrome; coronary, carotid, or peripheral vascular disease; 10-yr risk >20%.
  • Diabetes or CKD stages 3/4 with one or more risk factors.
  • HeFH.

High-risk patients: Goals: LDL <100 mg/dL, non-HDL <130 mg/dL, apoB <90 mg/dL

  • Two or more risk factors and 10-year risk 10-20%.
  • Diabetes or CKD stages 3/4 with no other risk factors.

Moderate-risk patients: Goals: Same goals as high risk

  • Two or more risk factors and 10-yr risk <10%.

Low-risk patients: Goals: LDL <130 mg/dL, non-HDL <160 mg/dL, apoB not relevant

  • 0 risk factors.

In order to summarise ,in contrast with 2013 guidelines from the American Heart Association and the American College of Cardiology, the AACE/ACE guidelines recommend LDL-C goals of <55 mg/dL, <70 mg/dL, <100 mg/dL, and <130 mg/dL for individuals at extreme, very high, high/moderate, and low risk for cardiovascular events, respectively, citing evidence that suggests that lowering LDL-C levels, regardless of starting point, is beneficial.

 For further reference log on to :

https://www.aace.com/files/lipid-guidelines.pdf

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Dr. Kamal Kant Kohli

Dr. Kamal Kant Kohli

A Medical practitioner with a flair for writing medical articles, Dr Kamal Kant Kohli joined Medical Dialogues as an Editor-in-Chief for the Speciality Medical Dialogues. Before Joining Medical Dialogues, he has served as the Hony. Secretary of the Delhi Medical Association as well as the chairman of Anti-Quackery Committee in Delhi and worked with other Medical Councils of India. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751
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