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Dementia in older women tied to 20-year rate of weight loss


Dementia in older women tied to 20-year rate of weight loss

For women surviving into late life, the rate of weight loss over 20 years is associated with development of mild cognitive impairment (MCI) or dementia, according to a study published online in the Journal of the American Geriatrics Society.

Erin S. LeBlanc, M.D., M.P.H., from Kaiser Permanente Northwest in Portland, Ore., and colleagues conducted a cohort study involving 1,289 older community-dwelling women (mean baseline age: 68 and 88 at cognitive testing). Participants underwent body weight measures repeatedly over 20 years.

The researchers found that the chance of developing MCI or dementia was increased for women with greater rate of weight loss over 20 years. Each 0.5 kg/year decrease resulted in 30 percent increased odds of MCI/dementia in age/education/clinic-adjusted base models . After further adjustment for age, education, clinic, depression, and walking speed, each 0.5 kg/year decrease was associated with a 17 percent increased odds of MCI/dementia. Variability in weight was significant in base models. The odds of MCI/dementia were increased 11 percent for each 1 percent average deviation from each woman’s predicted weight curve.After full adjustment the estimate was attenuated.

“Rate of weight loss over 20 years was associated with development of MCI or dementia in women surviving past 80 years,” the authors write.

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supriya kashyap

supriya kashyap

Supriya Kashyap Joined Medical Dialogue as Reporter in 2015 . she covers all the medical specialty news in different medical categories. She also covers the Medical guidelines, Medical Journals, rare medical surgeries as well as all the updates in medical filed. She is a graduate from Delhi University. She can be contacted at supriya.kashyap@medicaldialogues.in Contact no. 011-43720751
Source: Press Release

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