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Insulin glargine 300 safe, effective in elders with Diabetes : SENIOR Trial

Insulin glargine 300 safe, effective in elders with Diabetes : SENIOR Trial

Safety and efficacy of insulin glargine 300 units/mL (Gla-300) in older adults with type 2 diabetes (T2D) is equivalent to that of  Gla-100, with a similarly low or lower risk of symptomatic hypoglycemia, according to a study published in the journal Diabetes Care.

Robert Ritzel, Städtisches Klinikum München GmbH in Munich, Germany, conducted the study to compare the efficacy and safety of Gla-300 with Gla-100 in older people (≥65 years old) with type 2 diabetes.

Insulin glargine (Lantus) is a long-acting basal insulin analog which is given once daily to help control the blood sugar level of those with diabetes.

The open-label, two-arm, parallel-group, multicenter phase 3b SENIOR trial enrolled ∼20% of participants aged ≥75 years.   A total of 1,014 participants were randomized 1:1 to Gla-300 or Gla-100, titrated to a fasting self-monitored plasma glucose of 5.0–7.2 mmol/L.

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Key Findings:

  • From baseline to week 26, the reductions in HbA1c were comparable for Gla-300 and Gla-100 in the overall population and for participants aged ≥75 years
  • Similar and low incidence and rates of confirmed or severe hypoglycemic events were reported between the groups, with lower rates of documented symptomatic hypoglycemia with Gla-300.
  • Compared with the overall population, the subgroup aged ≥75 years had a more apparent lower risk of hypoglycemia with Gla-300 versus Gla-100.
  • The annualized rates of documented symptomatic hypoglycemia were significantly lower with Gla-300 (Gla-300, 1.12 versus Gla-100, 2.71; rate ratio, 0.45).

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Based on the study, the authors concluded that efficacy and safety of Gla-300 were demonstrated in older people (≥65 years of age) with type 2 diabetes, with comparable reductions in HbA1c and similarly low or lower risk of documented symptomatic hypoglycemia versus Gla-100. A significant benefit of hypoglycemia reduction was seen in participants aged ≥75 years.

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Source: With inputs from Diabetes Care

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