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    • India Antibiotic...

    India Antibiotic Guideline For Neonatal Infections

    Written by supriya kashyap kashyap Published On 2017-06-26T13:03:53+05:30  |  Updated On 26 Jun 2017 1:03 PM IST
    India Antibiotic Guideline For Neonatal Infections

    In 2016 National Centre For Disease, Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India came out with National Treatment Guidelines for Antimicrobial Use in Infectious Diseases.



    Following are major recommendationw


    Neonatal Infections :


    a. SEPTICEMIA OR PNEUMONIA


    1. In asymptomatic babies at high risk of sepsis eg. presence of foul smelling liquor or two or more risk factors listed below warrants the initiation of antibiotic therapy.


    Risk factors for Early onset sepsis are :


    (a) Maternal fever (Temperature > 380C) before delivery or during labor


    (b) Membranes ruptured for more than 24 hours before delivery.


    (c) More than three vaginal examinations during labor.


    (d) Low birth weight (<2500 gms) or preterm babies.


    (e) Prolonged and difficult delivery with instrumentation. 40


    (f) Perinatal asphyxia. (Apgar < 4 at 1 min of age) (g) Meconium stained liquor.


    2. A sepsis screen should be done in such infants. If two sepsis screens (NNF protocols) done at 12 hours interval or a single sepsis screen is negative and infant remains asymptomatic at 48 -72 hours, the antibiotics may be discontinued.




















    AntibioticEach doseFrequency




    < 7 days > 7 days
    RouteDuration(Days)
    Inj. Ampicillin And

    Inj. Gentamicin
    50 mg/kg/dose

    5-7.5 mg/kg/dose
    12 hrly 8hrly

    24 hrly 24hrly
    IV

    IV
    7-10



    7-10


    • In cases with severe sepsis (Sclerema/ Shock / suspicion of meningitis) Inj Cefotaxime 200 mg/kg/day IV in 4 div doses) + Amikacin (15mg/kg/d) is recommended

    • If sepsis is suspected to be health care associated or if there is no response in 48-72 hours of initial therapy or if there is documented resistance then change to injection Piperacillin- Tazobactam (200-300 mg/kg/day IV in 3-4 div doses) and Amikacin.

    • Vancomycin can be added to the regime if staphylococcus is suspected.


    b. NEONATAL MENINGITIS



























    AntibioticDoseFrequency




    < 7 days > 7 days
    RouteDuration

    (week)
    First LineInj. Ampicillin and



    Inj. Gentamicin
    100 mg/kg/



    dose 5-7.5 mg/kg/d
    12 hrly 8 hrly 5 mg/kg/d 7.5 mg/kg/d 24 hrly 24hrly IV





    IV
    3





    3
    Second LineInj. Cefotaxime and

    Inj. Gentamicin
    50 mg/kg/dose



    5-7.5 mg/kg/dose
    12 hrly 8 hrly 5



    mg/kg/d 7.5mg/kg/d

    24 hrly 24hrly
    IV





    IV
    3





    3

    You can read the full Guideline by clicking on the following link :


    http://www.ncdc.gov.in/writereaddata/linkimages/AMR_guideline7001495889.pdf

    Directorate General of health servicesGovernment of IndiaInfectious diseasesMinistry of Health &amp; Family WelfareNational Centre For Disease

    Disclaimer: This site is primarily intended for healthcare professionals. Any content/information on this website does not replace the advice of medical and/or health professionals and should not be construed as medical/diagnostic advice/endorsement or prescription. Use of this site is subject to our terms of use, privacy policy, advertisement policy. © 2020 Minerva Medical Treatment Pvt Ltd

    supriya kashyap kashyap
    supriya kashyap kashyap
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