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India Antibiotic Guideline for Cardiovascular Infections


India Antibiotic Guideline for Cardiovascular Infections

In 2016 National Centre For Disease Control, Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India came out with National Treatment Guidelines for Antimicrobial Use in Infectious Diseases.

Following are major recommendation

Cardiovascular Infections:

Condition Likely causative Organism Empiric antibiotics (presumptive antibiotics) Alternative antibiotics Comments
Infective Endocarditis:

Native valve (awaiting cultures) Indolent

Viridans Streptococci, other Streptococci, Enterococci Penicillin G 20MU IV divided doses, 4 hourly

or

Ampicillin 2gm iv 4h AND

Gentamicin 1mg/kg im or iv 8h

Duration: 4-6 weeks

Vancomycin 15mg/kg IV 12 hourly (maximum 1g 12 hourly)//teicplani n 12mg/kg IV 12 hourly x 3 doses followed by 6 – 12 mg once daily IV depending upon severity + Gentamicin 1mg/kg IM or IV

8 hourly Duration: 4-6 weeks

or

Daptomycin 6mg/kg IV once a day Duration: 4-6 weeks

If patient is stable, ideally waitblood cultures.

Antibiotic choice as per sensitivity results.

Guidance from Infectious disease specialist or clinical microbiologist is recommended

Infective Endocarditis:

Native valve (awaiting cultures) In Severe Sepsis

S.aureus

(MSSA or MRSA) Risk for gramnegative bacilli

Vancomycin 25- 30 mg/kg loading followed by 15-20 mg/kg IV 12 hourly (maximum 1gm

12

hourly)/teicoplan in 12mg/kg IV 12 hourly x 3 doses followed

by 6 -12 mg once daily IV depending upon severity

AND

Meropenem 1gm IV 8h Duration: 4-6 weeks

Daptomycin 6mg/kg IV once a day

AND

Meropenem 1gm IV q8h

Duration: 4-6 weeks

Modify antibiotics based on culture results and complete 4-6 weeks of antibiotics
Infective Endocarditis: Prosthetic Valve awaiting Cultures Vancomycin 15mg/kg IV 12 hourly (maximum 1gm

12

hourly)/teicoplan in 12mg/kg IV 12 hourly x 3 doses followed by 6 -12 mg once daily IV

depending upon severity +

Gentamicin 1mg/kg q12h IV

Daptomycin can be used in place of Vancomycin/ Teicoplanin for patients unresponsive to or intolerant of Vancomycin/Tei coplanin or with Vancomycin/Gly copeptideresistant isolates Antibiotic choice as per sensitivity. Guidance from Infectious disease specialist or microbiologist is recommended.

You can read the full Guideline by clicking on the following link :

http://www.ncdc.gov.in/writereaddata/linkimages/AMR_guideline7001495889.pdf

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supriya kashyap

supriya kashyap

Supriya Kashyap Joined Medical Dialogue as Reporter in 2015 . she covers all the medical specialty news in different medical categories. She also covers the Medical guidelines, Medical Journals, rare medical surgeries as well as all the updates in medical filed. She is a graduate from Delhi University. She can be contacted at supriya.kashyap@medicaldialogues.in Contact no. 011-43720751
Source: self

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