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Type 2 diabetes increases risk of fatty liver disease, finds study

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Type 2 diabetes increases risk of fatty liver disease, finds study

Increased blood sugar in Type 2 diabetes mellitus (T2DM) is associated with risk for nonalcoholic fatty liver disease (NAFLD) and considered a major risk factor for clinically significant liver disease. The study has appeared in the Journal of Clinical Gastroenterology and Hepatology.

Type 2 diabetes is a risk factor for the development of cirrhosis and hepatocellular carcinoma. However, the risk factor that identifies persons with the highest risk for these outcomes is missing from unselected, population-based cohorts.

Diabetes is a disease that occurs when blood sugar, is too high. Blood sugar is the main source of energy and comes from the food consumed. Insulin, a hormone made by the pancreas, helps glucose from food get into your cells to be used for energy. Sometimes insulin production or utilisation is faulty as a result of which blood sugar though present in the blood doesn’t reach the cells.

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Using data from the Swedish National Diabetes Register, researchers compared the incidence of severe liver disease (defined as development of cirrhosis or hepatocellular carcinoma [HCC], liver failure, or liver-related death) in over 400,000 individuals with T2DM and over 2 million individuals without T2DM, matched on age, sex, and county of residence (controls). They also assessed risk factors for severe liver disease in the T2DM group.

During a median follow-up of 7.7 years, 1.3% of patients with T2DM and 0.6% of controls developed the severe liver disease (hazard ratio, 2.3; P<0.001). HCC rates were also significantly higher in individuals with T2DM versus controls (0.26% vs. 0.08%), as were liver-related death rates (0.49% vs. 0.22%). Among those with T2DM, independent predictors of severe liver disease included male sex, older age, higher body-mass index, hypertension, and renal abnormalities (lower glomerular filtration rate and microalbuminuria), whereas statin use was a protective factor.

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The risk for severe liver disease was increased in patients with type 2 diabetes compared to controls (hazard ratio, 2.28; 95% CI, 2.21–2.36). Risk factors associated with severe liver disease in persons with type 2 diabetes were higher age, male sex, hypertension, higher body mass index, lower glomerular filtration rate, microalbuminuria, and smoking. Statins were associated with a decreased risk of severe liver disease.

The researchers concluded that Persons with type 2 diabetes have an increased risk of severe liver disease. Knowledge of risk factors can be helpful in identifying persons with type 2 diabetes who have a high risk of severe liver disease. Future studies should evaluate how best to utilize these risk factors to develop more-targeted approaches to screening for NAFLD in clinical practice.

For further reference log on to :

Björkström K et al. Risk factors for severe liver disease in patients with type 2 diabetes. Clin Gastroenterol Hepatol 2019 Apr 19; [e-pub]. (https://doi.org/10.1016/j.cgh.2019.04.038)



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Source: self

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  1. It\’s very useful as patients should know what else to monitor other than Sugar levels…If you check once in a while and it\’s under control, no need to worry!

  2. Thanks for the Information regarding Non Alcoholic Fatty Liver Disease and Type 2 Diabetes.

  3. user
    Baidyanath Bhattacharjee May 13, 2019, 9:56 am

    Why creating fear psychosis? Every desease land to cancer. This type of writing should not be allowed. Typical Google guide. Disgusting.

  4. user
    Piyush B Pithadiya May 12, 2019, 9:12 pm

    Please don\\\’t share this type of things on social media. let people enjoy their life

  5. Please don\’t share this type of things on social media. let people enjoy their life.

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