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ICMR Antimicrobial Guidelines for Infections in Obstetrics and Gynaecology

ICMR Antimicrobial Guidelines for Infections in Obstetrics and Gynaecology

Indian Council of Medical Research, Department of Health Research has issued the ICMR Antimicrobial Guidelines for Infections in Obstetrics and Gynaecology. Following are the major recommendations :


The purpose of these guidelines is to ensure appropriate antimicrobial prophylaxis and treatment while at the same time limiting unnecessary use of antibiotics. Common gynaecological conditions which need treatment with antibiotics are pelvic inflammatory disease, bacterial vaginosis, vaginal candidiasis, vaginal trichomoniasis. Serious conditions include surgical site infection (SSI), puerperal sepsis and septic abortion. Antibiotic prophylaxis in surgical procedures reduces colonization by microorganisms introduced at surgery to a level which the patient’s immune system can overcome. Prophylactic antibiotics should be safe, inexpensive and effective against organisms likely to be encountered. Adequate serum and tissue levels should be present before an incision is made and therapeutic levels should be maintained during surgery and for a few hours after it is over.

Case definition:

Infectious complications following obstetric & gynaecologic surgery (eg caesarean section and hysterectomy) include SSI, urinary tract infection, endometritis, vaginal cuff cellulitis, perineal infection, and septicaemia.

Surgical Site Infection (SSI): These are defined by the centre for disease control, USA (CDC) and may be superficial, deep or involving organ/space.

i) Superficial incisional SSI: It occurs within 30 days after operation and involves only skin and subcutaneous tissue of the incision with at least one of the following:

  • Purulent drainage, with or without laboratory confirmation, from the superficial incision
  • Organisms isolated from an aseptically obtained culture of fluid or tissue from the superficial incision
  • At least one of the following: pain or tenderness, localised swelling, redness, or heat
  • Diagnosis of superficial incisional SSI made by a surgeon or attending physician.

ii) Deep incisional SSI: It occurs within 30 days after operation if no implant is left or within one year if implant is in place. The infection appears related to the operation and involves deep soft tissue (e.g. fascia, muscle) of the incision with at least one of the following:

  • Purulent drainage from deep incision but not from organ/space component of surgical site
  • A deep incision dehisces spontaneously or is deliberately opened plus at least one of the following features: fever (>38°C), localised pain or tenderness (unless culture-negative)
  • An abscess or other evidence of infection involving the deep incision is found on direct examination, during reoperation, or by histopathological or radiological examination
  • Diagnosis of deep incisional SSI made by a surgeon or attending physician

iii) Organ/space SSI: It occurs within 30 days after the operation if no implant is left in place or within one year if implant is in place. The infection appears related to the operation and involves any part of anatomy (e.g., organs and spaces) other than the incision which was opened or manipulated during an operation and at least one of the following:

  • Purulent drainage from a drain that is placed through a stab wound into organ/space
  • Organisms isolated from an aseptically obtained culture of fluid or tissue in organ/ space
  • An abscess or other evidence of infection involving the organ/space found on direct examination, during reoperation, or by histopathological or radiological examination
  • Diagnosis of organ/space SSI made by a surgeon or attending physician.

Puerperal sepsis: It is defined as “Infection of the genital tract occurring between rupture of membranes or labour and the 42nd day postpartum with 2 or more of the following”:

  • Pelvic pain
  • Pyrexia i.e. oral temperature 38.5°C or higher on any occasion
  • Abnormal vaginal discharge , e.g. presence of pus or discharge with foul odour
  • Delay in the rate of reduction of the size of the uterus (<2cm/day during the first 8 days)

Pelvic inflammatory disease (PID) comprises inflammatory disorders of upper genital tract, including endometritis, salpingitis, tubo-ovarian abscess, or pelvic peritonitis. The symptoms include fever, pelvic pain, dyspareunia and abnormal vaginal discharge. The diagnosis of PID would be likely in the presence of features listed below

  • Sexually active young women
  • Symptoms of pelvic or lower abdominal pain
  • Presence of cervical motion tenderness OR uterine tenderness OR adnexal tenderness on clinical examination.
  • No other cause identified for the above symptoms and signs

Vaginitis & cervicitis: comprises a spectrum of inflammatory disorders of the lower female genital tract characterised by vaginal discharge, odor, pruritus, and dyspareunia.

Common Pathogens:

The common organisms causing sepsis in the puerperium are mostly from endogenous microbiota of vagina and include streptococci (Group B), enterococci, lactobacilli, diphtheroids, Escherichia coli, genital mycoplasma, , Bacteroides sp and other anaerobes.

Following a CS – Organisms to cover would be Staphylococci, Streptococci, Enterococci, Lactobacilli, Diptheroids, E.coli, Anaerobic streptococci, Bacteroides and Fusobacterium spp. A meta-analyses showed that prophylaxis is definitely recommended and reduces fever, endometritis, SSI, UTI etc [Hofmeyr GJ, Smaill F. Antibiotic prophylaxis for cesarean section. Cochrane Database Syst Rev 2002; 3: CD000933]

The common organisms causing sepsis in gynaecologic surgery are polymicrobial and include enterococci, aerobic gram negative bacilli, gram positive cocci, Bacteroides spp and other anaerobes. Antibiotic resistant organisms include methicillin resistant Staphylococcus aureus (MRSA), vancomycin resistant Enterococcus (VRE), and extendedspectrum beta-lactamase-producing organisms. For majority of SSI, the endogenous flora of the vagina or the skin are responsible. Aerobic gram positive cocci, like staphylococci, are causative agents in majority of the cases but faecal flora (Enterobacter spp and E coli) may also contribute when the incision is near the perineum or groin.

Multicenter, randomized, double blind, active- and placebo-controlled study compared single doses of ampicillin, cefazolin, and placebo administered to women undergoing elective total abdominal hysterectomy at two centers in Thailand. The study found a significantly lower rate of infection, including superficial and deep SSIs, urinary tract infections, vaginal cuff infection, and pneumonia, with cefazolin (10.3%) compared with placebo (26.9%) and ampicillin (22.6%).[Chongsomchai C, Lumbiganon P, Thinkhamrop J et al. Placebo-controlled, double-blind, randomized study of prophylactic antibiotics in elective abdominal hysterectomy. J Hosp Infect 2002; 52:302–306.]

The staphylococci may be MSSA (methicillin senstitive Staphylococcus aureus) or MRSA, the latter more likely when the patient is referred after treatment at some other health care facility. During procedures like hysterectomy, which involve opening of the vaginal cuff, the surgical site may be exposed to a variety of anaerobes and aerobes from the vaginal microflora. There is evidence that the cervical region and surrounding uppermost part of vagina has less number of anaerobes and aerobes of proteobacteria which are responsible for majority of infections.

Common pathogens causing pelvic inflammatory disease (PID) are, C. trachomatis, N. gonorrhoeae, Bacteroides, peptostreptococci, mycoplasma, Gardnerella vaginalis, Haemophilus influenzae, enteric Gram-negative rods, Streptococcus agalactiae and anaerobes. Common pathogens causing vaginitis are candida species, Trichomonas vaginalis and organisms causing bacterial vaginosis like Gardnerella, peptostreptococci, Bacteroides, anaerobes, ureaplasma and mycoplasma. Common pathogens causing cervicitis are chlamydia and N. gonorrhoeae.


Blood culture and other samples are guided by clinical suspicion of focus of infection, such as mid-stream urine, vaginal swab, cervical swab, throat swab, placental swabs, sputum, cerebrospinal fluid, epidural site swab, caesarean section or episiotomy site wound swabs should be obtained prior to starting antibiotics. Antibiotics should be given as soon as possible. Results of laboratory tests should be checked and the microbiologist consulted to ensure optimum antimicrobial therapy.

Resistance pattern of common pathogens: in % susceptible (ICMR data 2014)


Amikacin 53
Cefepime 17
Cefoperazone/Sulbacta m 40
Cefotaxime 13
Ceftazidime 14
Chloramphenicol 72
Ciprofloxacin 35
Colistin* 96
Gentamicin 46
Imipenem 71
Meropenem 46
Piperacillin/Tazobactam 42
Tetracycline 55
Ertapenem 48

Staphylococcus aureus

Ciprofloxacin 68
Erythromycin 58
Clindamycin 68
Cefoxitin 51
Netilmicin 99
Vancomycin 100
Teicoplanin 100

Pseudomonas aeruginosa

Amikacin 93
Ceftazidime 68
Cefepime 51
Pip-taz 99
Imipenem 83
Cefoperazone 68
Meropenem 70
Cefo-sulbactam 56
Colistin 100
Ciprofloxacin 80

Acinetobacter baumannii

Amikacin 18
Cefepime 2
Cefoperazone/Sulbacta m 10
Cefotaxime 6
Ceftazidime 2
Chloramphenicol 26
Ciprofloxacin 10
Colistin 100
Imipenem 41
Meropenem 46
Piperacillin/Tazobactam 11
Tetracycline 32
Tobramycin 36
Ampicillin/Sulbactam 21
Ertapenem 0
Gentamicin 18

Antibiotic prophylaxis regimens:

I. Obstetrics:

a. Vaginal Delivery: Antibiotics are not routinely recommended. Women who do not know their Group B streptococcus (GBS) status are given antibiotics in situations mentioned in table II.

Antibiotic regimens:

  • Ampicillin 2 gm I V initial dose followed by 1gm IV 4-6 hrly till delivery for GBS prophylaxis. If allergic, Vancomycin 1 gm IV 12 hrly
  • Third / fourth degree perineal tear: Single dose Cefotetan or Cefoxitin 1 gm IV, after sensitivity testing (or clindamycin 600-900 mg IV , if allergic). The alternates are: IV cefuroxime 1.5 gm plus metronidazole 500 mg or IV amoxicillin-clavulanic acid 1.2 gm.

b. Preterm pre-labour rupture of membranes: Ampicillin 2 gm followed by 1 gm IV 4- 6 hourly for 48 hours followed by oral amoxycillin for 5 days PLUS oral erythromycin stearate 250-500 mg 6th hourly for 7 days.

c. Caesarean Delivery: Antibiotic prophylaxis is recommended for all caesareans

  • Single dose of first generation cephalosporin, iv Cefazolin, 2 gm, within 60 minutes before incision. Minimum interval before incision should be 15 min, preferably 30 min
  • If allergic to Cefazolin, give single dose of iv Clindamycin 600-900 mg + Gentamicin 80 mg

After single dose, therapeutic drug level is maintained for 3-4 hrs; repeat dose if duration of surgery is >3 hrs or blood loss is >1500 ml. Cefazolin prophylaxis is recommended even for those receiving ampicillin during labour for GBS prophylaxis. This is because ampicillin is less effective against MSSA, the chief cause of SSI, due to beta lactamase production. If the patient is already receiving appropriate antibiotics (e.g., for chorioamnionitis), then cefazolin prophylaxis may be omitted.

d. Rescue cervical encerclage: Ampicillin 2 gm IV single dose to reduce the risk of infection due to exposed membranes in the vagina.

II. Gynaecological Surgery

a. Hysterectomy and surgeries for pelvic organ prolapse and/or stress urinary incontinence: All women undergoing laparoscopic / vaginal / abdominal hysterectomy (VH, AH), or surgery for stress urinary incontinence should receive prophylactic antibiotics.

  • Single dose of cefazolin 2 gm IV. Dose is 3 gm if weight is >100 kg. The alternate is a second-generation cephalosporin like cefuroxime.
  • If allergic to cephalosporins, use Clindamycin 600 mg IV
  • Administer 15 to 60 minutes prior to incision. Additional dose is given 3 hours after the initial dose if surgical procedure is lengthy (e.g. >3 hours), or blood loss is >1500 mL
  • Give oral metrogyl 500 mg BD x 7 days, starting at least 4 days before surgery, to prevent post-operative vaginal cuff infection if there is evidence of bacterial vaginosis.

b. Other gynaecological procedures:

  • Laparoscopy (uterus and/or vagina not entered) / Hysteroscopy / Ectopic pregnancy: Single dose of Cefazolin 1 gm IV (if allergic, use clindamycin 600 mg). Alternate is a second-generation cephalosporin like cefuroxime. Give oral doxycycline 100 mg twice daily for 5 days post-operatively if there is history of PID or if fallopian tubes are dilated at procedure.
  • Abortions: Women undergoing an induced abortion (surgical or medical) must receive antibiotics effective against Chlamydia trachomatis and anaerobes. There is no need of antibiotics following curettage for a missed or incomplete abortion. Regimens: doxycycline 100 mg oral twice daily for 7 days, starting on day of abortion, plus metronidazole 800 mg oral at time of abortion OR azithromycin 1 g oral plus metronidazole 800 mg oral at time of abortion
  • HSG: oral doxycycline 100 mg prior to procedure, to be continued twice daily for 5 days if there is history of PID or fallopian tubes are found dilated at procedure

III. Emergency area (septic cases)

a. Puerperal sepsis / Septic induced abortion / chorioamnionitis: Inj. Piperacillin + Tazobactam 4.5 gm IV 8 hrly X 7-14 days. If patients have received antibiotics elsewhere OR have septic shock OR are intubated, consider optimum and appropriate antibiotics like Vancomycin , Imipenem and Teicoplanin to cover MRSA. Important to consider and cover C. sordelli and C. perfringens

Table I Antimicrobial spectrum of AMAs:

Antimicrobial drug Organisms sensitive Organisms resistant
Ampicillin Gram positive bacteria: Streptococcus pneumoniae, Streptococcus pyogenes, some isolates of Staphylococcus aureus (but not penicillin-resistant or methicillin-resistant strain), and some Enterococci.

Gram negative bacteria: Neisseria meningitidis, some strains of Haemophilus influenzae, and Enterobacteriaceae Actinomyces spp.

Cefazolin MSSA, Aerobic gram positive (S. aureus, S. epidemidis, S. pyogenes, S. pneumoniae), Aerobic gram negative if not ESBL or CRE (E. coli, Proteus)

ESBL: Extended Spectrum Beta Lactamase producing Bacteria CRE: Carbapenem Resistant Enterobacteriaceae

MRSA, Enterococci, anaerobes
Cefuroxime Aerobic gram positive (pneumococci, S. pyogenes, S. aureus), aerobic Gram negative if not ESBL or CRE (E. coli, H influenzae, K. pnemoniae, N. gonorrhoeae) MRSA, Enterococci, anaerobes
Cefotetan Like second generation: additional = anaerobes: Bacteroides
Metronidazole / Tinidazole Broad array of gut anaerobes, protozoa, and microaerophilic bacteria.

Bacteroides spp, Clostridium spp, Prevotella spp, Porphyromonas sp p, Fusobacterium spp, Clostridium spp

Also anaerobic protozoa: T. vaginalis, E.histolytica, Giardia lamblia, Blastocystis hominis, Balantidium coli

Propionibacterium acnes,

and Lactobacillus spe cies are resistant to


Piperacillin + Tazobactum MSSA, Coagulase negative Staphylococci if Methicillin susceptible, Streptococcus pneumoniae (penicillin susceptible), Streptococcus spp., Haemophilus influenzae, Neisseria gonorrhoeae, Enterobacteriaceae, E. coli, Pseudomonas aeruginosa MRSA
Clindamycin Staphylococci, Streptococcus viridans, Streptococcus pyogenes, and Streptococcus pneumoniae

Potent activity against anaerobes such as B. fragilis, Clostridium perfringens, Fusobacterium spp, Prevotella melaninogenicus, Peptostreptococcus spp, Actinomyces spp

H. influenzae, enterococci, Neisseria meningitides, Mycopla sma pneumoniae and aerobic g
Vancomycin MRSA

Table 2 Summarizing use of Anti Microbial Agents (AMA) in Obstetrics & Gynaecology

S. no. Clinical condition / procedure Common pathogens Preferred AMA Alternate AMA Comments














Vaginal delivery: For GBS (Group B Streptococcus) prophylaxis in women who do not know their GBS status in the following situations:

  • Preterm labour (< 37 wks)
  • Prolonged rupture of membranes (>18 hrs)
  • Fever during labour or chorioamnionitis
  • History of previous baby with GBS infection
  • Bladder or kidney infection due to GBS
Group B Streptococci














Ampicillin 2 gm IV followed

by 1gm

IV 4-6 hrly till delivery











Cefazolin 2 g IV followed by 1 g 8 hrly till delivery

If allergic, Vancomycin 1 gm IV 12 hrly till delivery











Not recommended routinely for normal vaginal delivery

Delivery is considered akin to drainage of an abscess as the fetus and placenta is removed which are the nidus of infection

















3rd or 4th degree Perineal tear










Gram positive Staph. aureus, Gram negative Enterobacteria ceae, Anaerobes







Single dose cefoxitin or cefotetan 1gm IV








Single dose Cefazolin 1 gm IV plus metronidazole 500 mg IV

OR single dose IV cefuroxime 1.5 gm plus metronidazole 500 mg IV

OR single dose IV 1.2 gm amoxicillinclavulanic acid .

if allergic, single dose IV clindamycin 600- 900 mg

Prophylaxis is considered to prevent adverse outcomes arising from infection eg fistulas















Preterm pre-labour rupture of membranes







Gram positive


Gram negative: Enteric gramnegative bacilli, Ureaplasma, mycoplasma Anaerobes (including G. vaginalis),

IV Ampicillin 2 gm followed by 1 gm 4-6 hourly for 48 hours followed by oral amoxycillin 500 mg 8 hourly for 5 days PLUS oral erythromycin 333 mg 8 hourly for 7 days If erythromycin 333 mg is not available, use erythromycin stearate 250 mg 6 hourly for 7 days




































Caesarean delivery






























Gram positive aerobes: GBS, Staphylococci, enterococci, Gram negative Aerobes: E. coli, Klebsiella, Proteus Anaerobic Gram-positive cocci Peptococci, peptostreptoco cci

Anaerobic Gramnegative bacilli: Bacteroides, Prevotella spp. Facultatively anaerobic Gram-variable rod: G. vaginalis











Single dose cefazolin 2gm IV

Dose is 3gm if patient is >100kg





















If allergic, single dose clindamycin 600-900 mg IV + Gentamicin 1.5mg/kg IV























Puerperal endometritis is polymicrobial, (aerobic– anaerobic). These organisms are part of vaginal flora and are introduced into the upper genital tract coincident with vaginal examinations during labour and/or instrumentation during surgery

Tita et al showed the addition of 500-mg azithromycin to cefazolin for cesareans (in labor or with membranes ruptured) reduced Endometritis & wound infection significantly (6.1% vs. 12.0%, P<0.001), endometritis (3.8% vs. 6.1%, P=0.02) wound infection (2.4% vs. 6.6%, P<0.001).




Rescue cervical encerclage


Vaginal flora



Inj Ampicillin 2 gm single dose


To prevent ascending infection from vaginal flora to exposed membranes















Puerperal sepsis / Septic abortion / chorioamnionitis














Gram positive: Streptococci (A,B,D), Staph. aureus

Gram negative: E.coli, Enterobacteria ceae including Klebsiella, Enterobacter, Citrobacter, Pseudomonas aeruginosa, Proteus mirabilis, Gardnerella vaginalis, Bacteroides Clostridium perfringes, Anaerobes

Inj. Piperacillin + Tazobactem 4.5 gm IV 8 hrly X 7-14 days













Clindamycin 600-900 mg IV 8 hourly+ Gentamicin 60 mg IV 8 hourly+ metronidazole 500 mg IV 8 hourly


Ampicillin-Sulbactam 3 g IV Q6H









Usually antimicrobial

































Hysterectomy (AH, VH, Laparoscopic) and surgeries for pelvic organ prolapse and/or stress urinary incontinence















Polymicrobial: Gram positive: Staphylococci, Gram Negative: enterococci, aerobic gram negative, Anaerobes Bacteroides spp,












Cefazolin 2 gm IV single dose

Dose is 3 gm if patient is >100kg















Cefuroxime 1.5 g IV single dose


If allergic to cephalosporin, Clindamycin 600 -900 mg IV + gentamicin 1.5mg/kg IV












In AH & LH, vagina is opened at end of procedure & exposure to vaginal flora is brief.

In VH, there is greater colonisation of surgical site. In AH for cancer with resection of upper vagina, there may be colonization with anaerobes. In such cases, metronidazole 500 mg IV may be added. If BV is suspected, oral metronidazole 500 mg BD for 7 days is given, beginning at least 4 days pre-op




Laparoscopy (uterus and/or vagina not entered) / Hysteroscopy / Ectopic pregnancy Skin commensals: Staph. aureus


Cefazolin 1 gm IV single dose.


Cefuroxime 1.5 g IV sinlge dose

If allergic, use IV clindamycin 600 mg






Abortions (medical and surgical)




Chlamydia, Neisseria gonorrhoeae



Azithromycin 1 g orally plus metronidazole 800 mg orally

at time of abortion

Doxycycline 100 mg orally twice daily for 7 days, starting on day of abortion, plus

metronidazole 800 mg orally at time of abortion

No prophylaxis for missed / incomplete abortion













Chlamydia, Neisseria gonorrhoeae




Doxycycline 100 mg orally before procedure



Doxycycline continued twice daily for 5 days if there is history of PID or fallopian tubes are dilated at procedure













Pelvic Inflammatory disease (mild to moderate)












N. gonorrhoeae, C. trachomatis and anaerobes

E. coli, Bacteroides GBS, GAS, S. aureus, respiratory pathogens (eg, H. influenzae, S. pneumoniae,







NACO: Tab. Cefixime 400 mg orally STAT


Tab. Metronidazole 400 mg BD X 14D


Cap. Doxycyline, 100 mg bd X 14 D



CDC: Levofloxacin 500 mg OD X 14 days


Ofloxacin 400 mg OD X 14 days With or without Metronidazole 500 mg BD X 14 days


Ceftriaxone 250 mg IM single dose plus Doxycycline orally 100 mg BD X 14 days with or without Metronidazole 500 mg BD X 14 days












Pelvic Inflammatory disease (severe) eg tubo-ovarian abscess, pelvic abscess









Cefotetan 2 g IV BD PLUS doxycycline 10 0 mg orally or IV BD








Cefoxitin 2 g IV every 6 hours PLUS Doxycycline 100 mg orally or IV every 12 hours OR Clindamycin 900 mg IV every 8 hours PLUS gentamicin loading dose IV or IM (2 mg/kg), followed by maintenance dose (1.5 mg/kg) every 8 hours. Single daily dosing (3– 5 mg/kg) can be substituted


An attempt should be made to obtain cultures and deescalate based on that.

Duration is two weeks, but can be extended depending upon clinical situation. Antibiotics may be altered after obtaining culture reports of pus/or blood







Vaginal candidiasis






C. albicans, C. glabrata, C. tropicalis





Tab Fluconazole 150 mg orally single dose OR local Clotrimazole 500 mg vaginal tablet once only


Miconazole, nystatin vaginal tablets/creams





Treat for 7 days in pregnancy, diabetes

Recurrent infections: 150 mg Fluconazole on day 1,4,7 then weekly for 6 months









Vaginal trichomoniasis








T. vaginalis








Tab.Secnidazo le 2 gm oral, single dose OR Tab. Tinidazole 500 mg orally, twice daily for 5 days OR Tab. Metronidazole 400 mg, twice daily for 7 days



Alcohol avoided during treatment and 24 hours after metronidazole or 72 hours after completion of tinidazole to reduce possibility of disulfiram-like reaction. Partner treatment essential









Bacterial vaginosis









Overgrowth of anaerobes (Gardnerella vaginalis)








Metronidazol e 400 mg orally BD X 7 days OR Metronidazol e gel 0.75%, one applicator (5 g) intravaginal x 5 days OR clindamycin Cream 2%, one applicator (5 g) intravaginal x 7 days Secnidazole 2 g orally OD X one day

OR Tinidazole 2 g orally OD X 2 days

OR Tinidazole 1 g orally OD X 5 days

OR clindamycin orally 300 mg BD X 7 days

OR clindamycin ovules 100 mg intravaginally OD HS for 3 days*

Refrain from sexual activity or use condoms during the treatment.

Clindamycin cream is oil-based and might weaken latex condoms




Guidelines by Indian Council of Medical Research :

Dr Soumya Swaminathan, Director General, Indian Council of Medical Research Secretary, Department of Health Research

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supriya kashyap

supriya kashyap

Supriya Kashyap Joined Medical Dialogue as Reporter in 2015 . she covers all the medical specialty news in different medical categories. She also covers the Medical guidelines, Medical Journals, rare medical surgeries as well as all the updates in medical filed. She is a graduate from Delhi University. She can be contacted at Contact no. 011-43720751
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    Dr Ramesh Vardhan March 17, 2017, 5:33 pm

    Instead of comming out with papers of Recommendation about antibiotics guidelines in an unseen NOT easily available media. I C M R Should have started NATION wise campaign in association with all the 472, Teaching MEDICAL COLLEGE HOSPITALS , GOVERNMENT And private health care providers. And also with People concerned with A D R / Adverse DRUG Reaction . They should see it that Schedule Drugs should be kept away from the reach of the unscrupulous elements. Other wise it will be doing more harm than good with increase in Antibiotics resistance Bacterial infections. Which is Bane to the Poor patients and Boon to Pharma companies.