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IBD patients are at higher risk of heart attack and mortality

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South Korea: Crohn’s disease (CD) patients are at a higher risk for heart attack or myocardial infarction (MI) and this risk is starker in female patients and those aged <40 years.

These are the findings of a recent study published in the journal Alimentary Pharmacology & Therapeutics.
Inflammatory bowel disease (IBD) is an umbrella term used to describe disorders that involve chronic inflammation of the digestive tract namely ulcerative colitis (UC) and Crohn’s disease. People with Crohn’s have inflammation throughout the digestive tract, while in ulcerative colitis, only the large intestine is inflamed.
“Inflammation plays an important role in coronary heart disease by triggering atherosclerosis-related processes, from plaque formation to thrombus rupture,” wrote the authors. “While IBD is an established risk factor for venous thromboembolism, its potential association with the development of coronary heart disease and stroke has been highlighted only recently.”
Dong Ho Lee, University Bundang Hospital, Seongnam, South Korea, and colleagues investigated whether IBD is associated with an increased risk of myocardial infarction, stroke or death.

The researchers used claim codes for identification of the patients diagnosed with IBD between 2006 and 2009 (10,708 with CD; 26,769 with UC) and they were matched with people who did not have IBD. They calculated risk for the three primary outcomes of myocardial infarction, stroke and death.

Also Read: Low BMI after 19 can lead to inflammatory bowel disease later in life

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Key findings include:

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  • Patients with CD had a higher risk for myocardial infarction than controls (incidence ratio = 1.64 per 1,000 person-years).
  • The risk was more prominent among patients older than 40 years (IR = 0.69 per 1,000 person-years) and among women (IR = 2.35 per 1,000 person-years).
  • Women with UC, but not men, were at higher risk for myocardial infarction (IR = 2.01 per 1,000 person-years).

Also Read: Bangalore scientists find cure of inflammatory bowel disease in pomegranate metabolite

“Patients with CD are at a higher risk of heart attack and mortality than in the general population. The higher risk of MI in female IBD patients and disease-specific mortality among IBD should be further studied in the future,” concluded the authors.

To read the complete study log on to https://doi.org/10.1111/apt.15446

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