This site is intended for Healthcare professionals only.

Huntington’s disease related to dysfunction in brain structure


Huntington’s disease related to dysfunction in brain structure

New York : Scientists have identified a link between Huntington’s disease and dysfunction in a section of brain structures that are critical for movement and impulse control.

Huntington’s disease is characterised by the progressive loss of nerve cells in the brain and affects approximately one in 10,000 people. This fatal disorder is caused by a hereditary defect in a single gene.

The findings may explain the causes of the debilitating symptoms such as as loss of motor and cognitive function, depression and personality changes that typically manifest in adulthood, as well as loss of brain tissue as the disease progresses.

For the study, the researchers used genetically engineered mice to carry the Huntington’s disease gene. They discovered that the electrical activity of the subthalamic nucleus was lost.

Impaired subthalamic activity was caused by anomalous receptor signalling, leading to defective energy metabolism and accumulation of damaging oxidants.

In addition, the abnormalities in the subthalamic nucleus was found to occur earlier than in other brain regions and that subthalamic nucleus nerve cells progressively degenerate as the mice age, mirroring the human pathology of Huntington’s disease.

“Our findings suggest early problems in the subthalamic nucleus not only contribute to the symptoms of Huntington’s disease, but are also likely to impair the processing capacity and health of other brain structures, more traditionally associated with the disease,” said Mark Bevan, professor at Northwestern University.

A better understanding of aberrant brain receptor signaling that leads to nerve cell dysfunction could reveal a target for therapy, the researchers said.

The study was published in the journal eLife.

The following two tabs change content below.
supriya kashyap

supriya kashyap

Supriya Kashyap Joined Medical Dialogue as Reporter in 2015 . she covers all the medical specialty news in different medical categories. She also covers the Medical guidelines, Medical Journals, rare medical surgeries as well as all the updates in medical filed. She is a graduate from Delhi University. She can be contacted at supriya.kashyap@medicaldialogues.in Contact no. 011-43720751
Source: IANS

Share your Opinion Disclaimer

Sort by: Newest | Oldest | Most Voted