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HbA1c between 7% and 8% okay for T2DM patients-New ACP Guidelines


HbA1c between 7% and 8% okay for T2DM patients-New ACP Guidelines

An HbA1C test measures a person’s average blood sugar level over the past two or three months. An HbA1C of 6.5 percent indicates diabetes.But according to new recommendations of American College of Physicians (ACP) there is no  proof of benefit for targets of HbA1c below 7%.Therefore in an evidence-based guidance statement ACP has suggested that HbA1c between 7%  & 8%  was okay  for most T2 DM patients. This implies that most patients  with type 2 diabetes should be treated to achieve an A1C between 7 percent and 8 per cent rather than 6.5 percent to 7 percent published today.The updated guidance has been published online in Annals of Internal Medicine.

 New ACP Guidelines offer four key statements-

  • Clinicians should personalize goals for glycemic control in patients with type 2 diabetes on the basis of a discussion of benefits and harms of pharmacotherapy, patients’ preferences, patients’ general health and life expectancy, treatment burden, and costs of care.
  • Clinicians should aim to achieve an HbA1c level between 7% and 8% in most patients with type 2 diabetes.
  • Clinicians should consider deintensifying pharmacologic therapy in patients with type 2 diabetes who achieve HbA1c levels less than 6.5%.
  • Clinicians should treat patients with type 2 diabetes to minimize symptoms related to hyperglycemia and avoid targeting an HbA1c level in patients with a life expectancy less than 10 years due to advanced age (80 years or older), residence in a nursing home, or chronic conditions (such as dementia, cancer, end-stage kidney disease, or severe chronic obstructive pulmonary disease or congestive heart failure) because the harms outweigh the benefits in this population.

“ACP’s analysis of the evidence behind existing guidelines found that treatment with drugs to targets of 7 percent or less compared to targets of about 8 percent did not reduce deaths or macrovascular complications such as heart attack or stroke but did result in substantial harms,” said Dr. Jack Ende, president, ACP. “The evidence shows that for most people with type 2 diabetes, achieving an A1C between 7 percent and 8 percent will best balance long-term benefits with harms such as low blood sugar, medication burden, and costs.”

ACP recommends that clinicians should personalize goals for blood sugar control in patients with type 2 diabetes based on a discussion of benefits and harms of drug therapy, patients’ preferences, patients’ general health and life expectancy, treatment burden, and costs of care.

The rationale in guidelines that recommended lower treatment targets (below 7 percent or below 6.5 percent) is that more intensive blood sugar control would reduce microvascular complications over many years of treatment. However, the evidence for reduction is inconsistent and reductions were seen only in surrogate microvascular complications such as the presence of excess proteins in the urine.

If patients with type 2 diabetes achieve an A1C of less than 6.5 percent, ACP recommends that clinicians consider de-intensifying drug therapy by reducing the dosage of current treatment, removing a medication if the patient is currently taking more than one drug, or discontinuing drug treatment.

“Results from studies included in all the guidelines demonstrate that health outcomes are not improved by treating to A1C levels below 6.5 percent,” Dr. Ende said. “However, reducing drug interventions for patients with A1C levels persistently below 6.5 percent will reduce unnecessary medication harms, burdens, and costs without negatively impacting the risk of death, heart attacks, strokes, kidney failure, amputations, visual impairment, or painful neuropathy.”

ACP also recommends that clinicians should treat patients with type 2 diabetes to minimize symptoms related to high blood sugar rather than targeting an A1C level in patients with a life expectancy less than 10 years due to advanced age (80 years or older) or chronic conditions (such as dementia, cancer, end-stage kidney disease, severe COPD or congestive heart failure, and patients residing in nursing homes), as the harms of A1C targeted treatment outweigh the benefits in this patient population.

“Although ACP’s guidance statement focuses on drug therapy to control blood sugar, a lower treatment target is appropriate if it can be achieved with diet and lifestyle modifications such as exercise, dietary changes, and weight loss,” said Dr. Ende.

Noting the policy implication of its recommendations, ACP suggests that any physician performance measures developed to evaluate quality of care should not have a target A1C level below 8 percent for any patient population and should not have any A1C targets for older adults (e.g., age 80 and older) or younger individuals with limited life expectancy because of other serious diseases and illnesses.

More than 30 million Americans have diabetes, and 90 percent to 95 percent of them have type 2 diabetes. Type 2 diabetes most often develops in people over age 45, but more and more children, teens, and young adults are also developing it.

ACP’s guidance statements involve a review and methodological critique of existing and sometimes conflicting guidelines rather than a systematic review of available evidence. “Hemoglobin A1C Targets for Glycemic Control with Pharmacologic Therapy in Non-Pregnant Adults with Type 2 Diabetes Mellitus” is derived from an appraisal of selected guidelines from around the world addressing A1C targets in the drug treatment of type 2 diabetes.

For more details click on the link: Annals of Internal Medicine, 2018; DOI: 10.7326/M17-0939

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Anjali Nimesh

Anjali Nimesh

Anjali Nimesh Joined Medical Dialogue as Reporter in 2016. she covers all the medical specialty news in different medical categories. She also covers the Medical guidelines, Medical Journals, rare medical surgeries as well as all the updates in medical filed. She is a graduate from Dr. Bhimrao Ambedkar University. She can be contacted at editorial@medicaldialogues.in Contact no. 011-43720751
Source: Press Release

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  1. Why we have to follow Western guide lines in all medical problem,why we Indian can not set our own standard?? In so many ways we Indian are different from them.

  2. I Aggre with Dr Ende as for any patient above 80yrs have type 2DM should be managed symptomatically by keeping pts hyperglycemia fbs about 120 to 140mg not just prescribing aggressive antidiabetic drugs to keep pts Hba1c below 6,5% otherwise pts suffer from drug toxic effects, &drugs costs will be detrimental.

  3. Does what apply to Western population also apply to our Indian people? How can it be perfected? Indian doctors must start generating their own demographic data for correct application of scientific practice. We differ in lot of respects from Western population, e.g., colour, ethnicity, climatically, food habits, living styles, sitting and defecation practices, etc. All these make a lot difference when it will come to application of treatment modules.