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    • Fecal Transplants...

    Fecal Transplants promising treatment for Antibiotic-Resistant C difficile infection

    Written by Hina Zahid Published On 2019-05-01T19:28:09+05:30  |  Updated On 1 May 2019 7:28 PM IST
    Fecal Transplants promising treatment for Antibiotic-Resistant C difficile infection

    Fecal Transplants is a promising treatment for Antibiotic-Resistant C difficile infection, find Mayo researchers.


    Transplanting human donor fecal microbiota into the colon of a patient infected with Clostridiodes difficile (C. diff) may be the best treatment for those not helped by C. diff targeted antibiotics, according to an article in The Journal of the American Osteopathic Association.


    C. diff is the most common healthcare-acquired infection in the United States. It affects nearly half a million patients each year and becomes a recurring infection for nearly a third of them. If untreated, C. diff can lead to sepsis and death. At present standard and FDA-approved treatment for C. diff is a course of oral vancomycin, an antibiotic.


    "Twenty-five years ago C. diff infections were easier to manage and often resolved with discontinuation of the initiating antibiotic," says Robert Orenstein, DO, an infectious disease specialist at Mayo Clinic and lead author on this article. "However, these infections have become increasingly common and pernicious."


    "Think of your gut as a forest and C. diff as a weed," says Dr. Orenstein. "In a thriving forest, weeds barely get a foothold. But if you burn the forest down, the weeds are going to flourish."


    Unlike antibiotics, which are destructive by definition, fecal transplants or microbial replacement therapies, repopulate the gut with a diverse group of microbes that may block the C. diff's spore from germinating and propagating disease via its toxins. Transplants have several delivery methods, including enemas, capsules and direct instillation, to replace the diverse flora that maintain health and improve metabolism.


    Currently, there are no FDA-approved fecal transplant products and performing fecal transplants is considered an investigational procedure. Dr. Orenstein notes there are several companies with products in Phase 3 clinical trials that could come to market as early as 2020. For this reason, he strongly urges healthcare providers to refer patients with recurrent C. diff for these trials rather than for fecal transplants. In the meantime, the FDA reserves fecal transplants for patients who have experienced a second recurrence (third episode) of C. diff infection.


    C. diff is common in healthcare settings and public spaces and rarely causes problems in people with healthy gut microbiota and immune systems, according to researchers. However, people who are already ill and taking antibiotics, chemotherapy, or proton pump inhibitors—which all greatly disrupt the gut ecosystem—are at risk. Elderly patients are especially vulnerable.


    Dr. Orenstein expects the new treatment options will improve outcomes but says physicians need to assume greater responsibility for prevention.


    "One of the most effective things physicians can do is become more responsible with antibiotic prescriptions," says Dr. Orenstein. "That means only prescribing when they are clearly indicated, not for colds or viral sinus infections. We also must be especially judicious with elderly patients."

    C. diffchemotherapyClostridiodes difficileFDAFecal transplantFecal Transplantsimmune systemsMayo Clinicmetabolismmicrobial replacement therapiesoral vancomycinProton pump inhibitorsRobert OrensteinsepsisThe Journal of the American Osteopathic Associationtoxins

    Disclaimer: This site is primarily intended for healthcare professionals. Any content/information on this website does not replace the advice of medical and/or health professionals and should not be construed as medical/diagnostic advice/endorsement or prescription. Use of this site is subject to our terms of use, privacy policy, advertisement policy. © 2020 Minerva Medical Treatment Pvt Ltd

    Hina Zahid
    Hina Zahid
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