The researchers found that cumulative incidences in individuals in the CGPS with and without FH causative mutations were similar for ischemic stroke but not for myocardial infarction at age 80. They found that there was no association between clinical FH and ischemic stroke, except if personal premature ischemic heart disease was included in the clinical FH criteria. Ischemic heart disease at baseline was associated with higher ischemic stroke risk, explaining its higher risk in those with high LDL cholesterol. For a 1mmol/L higher LDL cholesterol the genetic causal risk ratio was 1.11(0.62-2.02) for ischemic stroke and 1.45(1.08-1.93) for myocardial infarction.
The authors Concluded that FH and high LDL cholesterol did not confer an increased risk of ischemic stroke. A positive association with it observed for some clinical FH criteria and high LDL cholesterol appears to be due to previous ischemic heart disease, rather than by high LDL cholesterol per se.
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Dr. Kamal Kant Kohli
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